Boston Red Sox vs Toronto Blue Jays Picks and Predictions for Tuesday, September 23, 2025

By: David Anicetti Published 09/23/2025, 12:05 AM ET

The Boston Red Sox visit the Toronto Blue Jays on Tuesday at Rogers Centre at 7:07 PM ET on MLB.TV. Boston is 85–71 and sits third in the AL East after going 2–3 in its last five games, while Toronto is 90–66, leading the division, and comes in off an 8–5 win over Kansas City that ended a rough stretch. Boston currently holds the third and final AL wild card but only by one game, while Toronto leads the AL East by two games and has clinched a postseason berth. Throw a no-hitter and win with our best bets today.

Boston Red Sox Preview

Lucas Giolito gets the ball for Boston with a 10–4 record, 3.46 ERA, and 1.28 WHIP over 140.1 innings. The right-hander has 118 strikeouts but also 52 walks so command will be key. When Giolito gets ahead, he limits damage, giving up just 17 home runs all season. The right-hander has been one of Boston’s most consistent starters.

The Red Sox offense has been steady with a .255 average and 765 runs. Trevor Story leads with 25 homers, 95 RBI, and a .264 average, while Jarren Duran adds speed and a .336 on-base percentage. Alex Bregman has provided extra punch with an .835 OPS. Boston is even on the road at 39–39, which shows the club’s ups and downs away from Fenway.

Toronto Blue Jays Preview

Kevin Gausman starts for Toronto, holding a 10–10 record with a 3.38 ERA and 1.01 WHIP across 183.2 innings. The right-hander has piled up 177 strikeouts and allowed only 138 hits, showing how well he controls his starts when he keeps walks in check.

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The Blue Jays' lineup has been one of the most balanced in the league. Bo Bichette leads the team with a .311 average and 181 hits, while George Springer has 30 homers, 80 RBI, and a .305 average. Vladimir Guerrero Jr. continues to drive in runs with 83 RBI and a .299 average. As a team, Toronto is batting .267 with 768 runs and 182 home runs, and their 50–25 record at home shows how well they play at Rogers Centre.

Boston Red Sox vs Toronto Blue Jays Prediction

Both starters have been solid, and this sets up as a tight game. Giolito has kept the Red Sox in games all year, but Toronto’s deeper lineup and strong home record should give the Blue Jays the advantage once the bullpens take over. Final Score Prediction: Toronto Blue Jays win 4-3.