BC Lions vs. Calgary Stampeders Picks and Predictions for Friday, September 19, 2025

By: David Anicetti Published 09/15/2025, 11:41 PM ET

The West Division remains congested as the BC Lions visit the Calgary Stampeders Friday night. Both teams enter the matchup with playoff hopes in mind: BC sits at 7-5, while Calgary is slightly behind at 6-6. Kickoff is scheduled for 9:30 PM ET at McMahon Stadium. This is a pivotal clash of two teams built around strong quarterback play but trending in different directions. The CFL action is in full swing and you can jump in on some great winning bets with our free CFL Picks.

Game Information For Lions vs Stampeders

Date: Friday, September 19, 2025

Kickoff: 9:30 PM ET

Stadium: McMahon Stadium, Calgary, AB

Subscribe Now

I authorize Picks And Parlays to send me promotional emails

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Picks And Parlays may use third-party services to process my data.

Terms & Conditions

Broadcast: TSN, CFL+

BC Lions Preview

Nathan Rourke has been the driving force under center, completing 67.7% of his passes for 3,604 yards, 20 touchdowns, and 9 interceptions, with a passer rating of 109.1. In the receiving corps, Keon Hatcher leads with 71 catches for 1,170 yards and 5 touchdowns. In the run game, James Butler has carried 184 times for 989 yards at 5.4 yards per carry with 10 touchdowns.

The Lions’ defense has allowed an average of 356.8 total yards per game, with opponents averaging 249.6 passing yards and 107.2 rushing yards per game. The Lions are allowing over 29 points per game. Robert Carter Jr. and Garry Peters share the team lead in interceptions with two each, giving the secondary some playmaking ability. Up front, Mathieu Betts has registered 4 sacks, setting the tone for the pass rush. Peters has also been one of the most consistent tacklers.

Calgary Stampeders Preview

Vernon Adams Jr. is leading the Stampeders’ passing game with 2,826 yards. Dominique Rhymes is Adams’ favorite target with 609 yards and 4 touchdowns. The running game shares much of the load, with Dedrick Mills leading all rushers with 882 yards and 8 touchdowns, and Adams is a distant second with 180 yards and one touchdown.

Defensively, Calgary has allowed an average of 107.1 yards rushing and 252.2 yards passing for a total of 359.2 yards per game, which is third. The Stampeders are allowing an average of 20.4 points per game, which is the lowest in the CFL by 3.1 points per game (Saskatchewan 23.5 ppg).

Odds For Lions and Stampeders

Spread: BC -3.5

Moneyline: BC -165, Calgary +140

Total: 50.5

Stampeders vs Lions Prediction

BC’s offense sets them apart, as the Lions average 30.1 points per game, which is second-highest, while Calgary is averaging 26.7 points per game, which is 5th. The Lions will give up their share of points, but will overcome a tough Calgary defense with a strong passing game accompanied by an above-average ground game. Final Score Prediction: BC Lions win and cover ATS 33-24.