Baltimore Orioles vs Cleveland Guardians Picks and Predictions for Thursday, April 16, 2026

By: Cameron Ross Published 04/16/2026, 12:55 AM ET

Orioles vs Guardians Game Information

The Baltimore Orioles will be on the road Thursday night for a 6:10 PM matchup inside Progressive Field in Cleveland, OH, against the Cleveland Guardians. Baltimore comes into this matchup with nine wins and 9 losses on the year, riding a 2 game skid after a three-run loss in the 10th inning to the Arizona Diamondbacks last outing. The Cleveland Guardians return home Thursday with ten wins and 9 losses this season, having lost the last four, including two in a row, after a 2 run road loss to Saint Louis. Stay in the news with our MLB Picks.

Orioles Preview

Offensively, Baltimore has been solid this season, with a .248 batting average. The Orioles have scored 72 runs on 138 hits. Baltimore has a .337 OBP and a .397 slugging percentage. Baltimore has boasted a 3.83 team ERA this season, but has given up 12 total runs over their last two losses. Taylor Ward leads the Baltimore offense this season with a .301 batting average. Gunnar Henderson is the pop in the Baltimore lineup, leading the team with six home runs alongside a .221 batting average. Jeremiah Jackson has compiled a .340 batting average to go along with a team-leading fourteen RBI's this season.

Guardians Preview

The Cleveland offense has been lackluster this season, with a .228 team batting average. The Guardians have scored 72 runs on 134 hits. Cleveland has a .314 OBP and a .384 slugging percentage. The Cleveland pitching staff has been below average, with a 3.98 team ERA, and the Guardians have allowed 24 runs over their last three losses. Angel Martinez leads the way for the Cleveland offense this season with a .302 batting average. Chase DeLauter leads the team with five home runs and twelve RBIs on the season.

Orioles vs Guardians Pitching Matchup

Shane Baz takes the mound for Baltimore on Thursday, winless on the year with a 4.50 ERA across 16 innings of work. Parker Messick will take the mound Thursday for Cleveland with a 2-0 with a .51 ERA across 17.2 innings of action this year.

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Orioles vs Guardians Pick

Cleveland is the better team in this matchup, and it will show from the opening pitch on Thursday. Baltimore does have the better offense, but the Cleveland pitching edge will be the difference. Look for Cleveland to stifle Baltimore for 9 innings on Thursday, resulting in the victory. Take the Guardians to open this series Thursday with a win at home.

Pick: Cleveland Guardians -118
Secondary: Over 8
Lean: Taylor Ward Over 1.5 Bases

Final Score Prediction: Cleveland Guardians win 6-4.