Baltimore Orioles vs Chicago White Sox Picks and Prediction for Monday September 15 2025

By: Eddie Kline Published 09/15/2025, 12:40 AM ET

Orioles Preview

Rate Field will play host to a Monday night MLB clash between the Baltimore Orioles and the Chicago White Sox. Be ready for the baseball season with all of our MLB predictions. The Orioles (69-80) have lost three straight games and are stuck in the AL East Division basement. On Sunday, OF Colton Cowser and 1B Coby Mayo each went deep during an 11-2 road loss against Toronto. RP Carson Ragsdale was roughed up for eight runs in three innings.

Thirty-one year old righty Tyler Wells (1-0 2.31 ERA) will make his third start of the year for the Orioles. Last time out, Wells (6.1 IP) allowed just one run and struck out six batters during a 2-1 home victory versus Pittsburgh.

White Sox Preview

The Chicago White Sox are 11 games below .500 at home and own the worst overall record in the American League. On Sunday, Chicago batters went 0-for-4 with runners in scoring position and struck out 11 times during a 3-2 road loss against Cleveland. 2B Chase Miedroth homered in a losing effort for the White Sox (57-93), who are looking to avoid their third consecutive 100-loss season.

Twenty-five year old righty Sean Burke (4-10 4.35 ERA) will head to the hill for the White Sox in this contest. Control has been an issue for Burke, who has issued 58 walks and surrendered 21 home runs across 122 frames.

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Orioles vs White Sox Pick

Baltimore C Adley Rutschman (oblique) is currently on the 10-day injured list and hopes to return later this month. Through 149 games, Baltimore ranks 20th in OPS and 21st in runs scored. For the season, Chicago ranks 28th in OPS and 26th in runs scored. Take the over. Final Score Prediction, Baltimore Orioles win 6-4.