Baltimore Orioles vs Chicago White Sox Picks and Predictions for Monday, April 6, 2026

By: Cameron Ross Published 04/06/2026, 01:30 AM ET

Orioles vs White Sox Game Information

The Baltimore Orioles will be on the road Monday night for game one of three in Chicago against the Chicago White Sox. Baltimore has struggled thus far this season, coming into Monday with three wins and six losses, having lost four of the last five, including three in a row, after a six-run road loss to the Pittsburgh Pirates. The Chicago White Sox stay home Monday night with four wins and five losses this season on a three-game winning streak following a three-run victory against Toronto in their last outing. Stay in the news with our MLB Picks.

Orioles Preview

Physically, Baltimore has been stopped this season with a .241 batting average. The Orioles have scored 32 runs on 65 hits thus far this season. Baltimore has a .337 OBP and a .368 team slugging percentage. The Baltimore pitching has struggled, however, with a 4.22 team ERA. Gunnar Henderson leads the Baltimore offense this season with two home runs and six RBI's on the year. Taylor Ward boasts a team-leading .343 batting average.

White Sox Preview

Chicago has been below average on the offensive side this season, with a .212 batting average. The White Sox have scored 32 runs on 55 hits this season. Chicago has a .286 OBP and a .354 teams slugging percentage. Chicago pitching has been horrendous this season, with a 7.01 team ERA, but the team has allowed just seven runs during its current three-game winning streak. Tristan Peters leads the Chicago offense this season with a .304 batting average. Miguel Vargas leads the team with seven RBI's on the year, while Munetaka Murakami leads the team wit 4 homeruns this season.

Orioles vs White Sox Pitching Matchup

Baltimore has yet to decide on a pitcher for Monday night's game, giving Chicago the edge. Chicago will trot out Grant Taylor, who has boasted a 2.25 ERA thus far this season through 4 innings of work. The Chicago bullpen has been terrible, but Taylor can lead the way for them in this matchup. Baltimore, on the other hand, has a 4.22 team ERA this season and could potentially rely solely on the bullpen Monday night

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Orioles vs White Sox Pick

Shockingly, Chicago's been the better team thus far this season, and that will continue Monday night. Chicago was the underdog in this matchup, but it will have the better pitcher on the mound. Baltimore does have the better offense, but has struggled immensely heading into this matchup. Look for Chicago to extend their winning streak Monday night as they get a win at home to get to .500 on the year.

Pick: Chicago White Sox +123
Secondary: Under 9
Lean: Miguel Vargas Over.5 RBIS

Final Score Prediction: Chicago White Sox win 5-2.