Boston Red Sox vs. Arizona Diamondbacks Picks and Prediction for Friday September 5, 2025

By: Dylan Hellebrand Published 09/05/2025, 12:25 AM ET

On Friday, the Boston Red Sox (78-62) face off against the Arizona Diamondbacks (70-71) at Chase Field in Phoenix, Arizona. The game will be aired on NBC Phoenix and NESN. Keep up to date with all the MLB action, with our MLB picks.

Red Sox vs Diamondbacks Game Information:

September 5, 2025, 9:40pm EST, NBC Phoenix/NESN
94° at start time

Diamondbacks Form & Recent Results:

Arizona comes into this matchup on a two-game winning streak and has won three of their last five games. In their 2-0 victory over Texas on Wednesday, Diamondbacks starter Zac Gallen delivered a strong performance, tossing six scoreless innings. During his outing, Gallen scattered just four hits, issued one walk, and racked up five strikeouts, keeping Texas off the scoreboard and setting the tone for Arizona’s shutout win. Offensively this season, outfielder Corbin Carroll has been Arizona’s biggest power threat, leading the team with 29 home runs. Close behind him is infielder Ketel Marte, who has launched 25 homers so far, making him the club’s second-best in that category. When it comes to driving in runs, shortstop Geraldo Perdomo tops the Diamondbacks with 88 RBIs on the year, showing his knack for producing in key situations. Ketel Marte also stands out as Arizona’s most consistent hitter, boasting a team-best .290 batting average this season. Recently, the Diamondbacks’ offense has averaged 4.4 runs per game over their last five games, as they continue fighting to keep their fading playoff hopes alive. Throughout the whole year, the team has averaged 4.9 runs per game, reflecting a solid but not spectacular offensive lineup.

Red Sox Form & Recent Results

Boston enters this game on a three-game winning streak and has won three of their last five games prior to their series finale against Cleveland. In Tuesday's 11-7 victory over Cleveland, Ceddanne Rafaela delivered a standout performance for the Red Sox, going 2-for-4 at the plate. He crushed a home run as part of his effort, crossing the plate three times himself and driving in four runs to power Boston's offense. Trevor Story has been Boston’s top power hitter this season, leading the team with 23 home runs. Not far behind him is Wilyer Abreu, who has tallied 22 home runs, making him the Red Sox’s second-leading home run hitter so far this year. Story has also been Boston’s most productive run producer, topping the team with 88 RBIs for the season. He leads the Red Sox not only in runs batted in, but also in batting average, boasting a .261 mark at the plate. Lately, the Red Sox lineup has been especially effective, averaging 5.4 runs per game over their last five contests as they try to close the gap in the AL East standings. Currently, Boston trails Toronto by just two and a half games for first place in the division. Overall, the Red Sox have averaged 5 runs per game, underscoring their strong offensive presence.

Red Sox vs Diamondbacks Recent Betting Trends

Boston is 34-35 on the road this season
The Red Sox average 5.1 runs on the road
Arizona is 36-33 at home this season
The Diamondbacks average 5.2 runs at home

Red Sox vs Diamomdbacks Pitching Matchup:

Boston’s Payton Tolle (0-0, 3.38 ERA) vs. Arizona’s Eduardo Rodriguez (6-8, 5.40 ERA)
Tolle in last game: 5.1 IP, 3 hits, 2 ER, 2 walks, 8 k
Rodriguez at home: 1-2, 5.69 ERA

Red Sox vs Diamondbacks Picks and Prediction:

Boston is currently in pursuit of first place in their division, hoping to catch up with the Blue Jays. Meanwhile, Arizona is focused on securing a wild card spot, though their chances of making the postseason are quite slim at this point. However, a strong showing in their upcoming home series against the Red Sox could significantly improve their odds and keep their playoff hopes alive. On the mound for Boston will be Payton Tolle, who has been a reliable presence this year with an earned run average of 3.38, indicating solid performances in his outings so far. Arizona will counter with Eduardo Rodriguez, whose season has been marked by inconsistency, as he holds a 6-8 win-loss record and a 5.40 ERA. Final Score Prediction, Boston Red Sox win 3-2.

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