Boston Red Sox vs Tampa Bay Rays Picks and Predictions for Saturday, September 20, 2025

By: David Anicetti Published 09/20/2025, 12:10 AM ET

The Boston Red Sox visit the Tampa Bay Rays on Saturday at George M. Steinbrenner Field. The first pitch is at 7:05 PM ET on MLB.TV. Boston is 83–70, third in the AL East, and has gone 2–3 in its last five, splitting a series with Oakland after two close games against the Yankees. Tampa Bay is 75–78, fourth in the AL East, and is 2–3 in its last five after back-to-back wins over Toronto. Boston currently holds the third and final AL wild card, while Tampa Bay is 8 games behind. Steal a base with free MLB picks.

Boston Red Sox Preview

The Red Sox have shown steady power at the plate. Trevor Story leads the way with a .268 average, 25 home runs, and 93 RBI. Jarren Duran has been an on-base spark with a .335 on-base percentage and 23 steals, while Alex Bregman has chipped in with 17 homers and a .464 slugging percentage. Boston’s lineup as a whole sits at .254 with 180 home runs and has been able to generate runs from the top and middle of the order.

On the mound, left-hander Kyle Harrison gets the ball. He is 1–1 with a 4.05 ERA and 27 strikeouts in 26.2 innings. Boston’s staff has been sharp overall with a 3.73 ERA and a 1.29 WHIP. Harrison’s key will be throwing strikes early and letting Boston’s bullpen handle the later innings. If he limits walks, the Red Sox should be in good shape on the road.

Tampa Bay Rays Preview

The Rays continue to ride Junior Caminero and Yandy Díaz. Caminero leads the club with 44 home runs and 108 RBI, while Díaz is hitting .297 with 167 hits and a .361 on-base percentage. Jonathan Aranda has also provided a lift with a .316 average and steady run production. Team-wide, Tampa Bay is batting .252 with 173 home runs, but has had trouble putting together big innings in recent weeks.

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Adrian Houser brings experience to this matchup. The right-hander is 8–4 with a 3.11 ERA and 113.0 innings pitched. Tampa Bay’s staff has held a 3.83 ERA and 1.20 WHIP, showing good control and allowing few runs. Houser’s command gives the Rays a chance to keep Boston’s bats quiet, especially in the early frames.

Boston Red Sox vs Tampa Bay Rays Prediction

Boston has the stronger lineup from top to bottom and a pitching staff that has been reliable through most of the season. Tampa Bay will compete behind Houser, but the Red Sox have more ways to create runs and should come away with the win in a close game. Final Score Prediction: Boston Red Sox win 4-3.