Chicago Cubs vs Philadelphia Phillies Picks and Prediction for Wednesday April 15 2026

By: Eddie Kline Published 04/15/2026, 01:10 AM ET

Cubs Preview

Citizens Bank Park will play host to a Wednesday night MLB clash between the Chicago Cubs and the Philadelphia Phillies. Be ready for the baseball season with all of our MLB predictions. The Cubs (8-9) have split their first eight road games and are currently in the NL Central Division basement. Last night, Alex Bregman went 3-for-5 with three RBIs to lead Chicago to a 10-4 road triumph against Philadelphia. C Carson Kelly added a three-run shot in the ninth inning to seal the win for the Cubs.

For the Cubs to be serious NL Central Division contenders, right-hander Shota Imanaga (0-1 2.81 ERA) must figure prominently. In three starts this year, Imanaga (16 IP) has allowed just one long ball while fanning 20 batters.

Phillies Preview

The Philadelphia Phillies are a game below .500 at home and are in search of their third consecutive NL East Division title. During Tuesday’s home loss, 3B Edmundo Sosa put Philadelphia on the scoreboard with a three-run blast. SP Aaron Nola gave up three runs in five innings and did not factor in the decision for the Phillies.

Philadelphia manager Rob Thomson will give the nod to talented lefty Jesus Luzardo (1-2 6.23 ERA) in the series finale. In his last start, Luzardo (4.2 IP) gave up five runs and struck out eight batters during a 5-4 home loss versus Arizona.

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Cubs vs Phillies Pick

Philadelphia SP Zack Wheeler (shoulder) made another successful rehab start for Triple-A Lehigh Valley and hopes to make his season debut later this month. Through 17 games, Chicago ranks 19th in OPS and 12th in runs scored. For the season, Philadelphia ranks 11th in OPS and 22nd in runs scored. Take the under. Final Score Prediction, Philadelphia Phillies win 4-3.

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