Chicago White Sox vs Chicago Cubs Picks and Prediction for Wednesday August 19 2026
White Sox Preview
Crosstown rivals will square off on Wednesday afternoon, when the Chicago White Sox take on the Chicago Cubs from historic Wrigley Field. Be ready for the baseball season with all of our MLB predictions. The White Sox (65-60) are eight games below .500 on the road and are four games clear of Minnesota for AL Central Division supremacy. Last night, White Sox batters went 2-for-11 with runners in scoring position and left eight men on base during a 4-3 road loss against the Cubs. 1B Munetaka Murakami clobbered his 29th long ball of the year.
Chicago manager Will Venable has not announced a starting pitcher for the series finale. The White Sox currently rank in the middle of the pack with a 4.15 ERA and a respectable 1.30 WHIP. Chicago starters have notched an underwhelming 31 quality starts on the year.
Cubs Preview
The Chicago Cubs have won seven of their last 11 games and are sitting comfortably atop the National League Wild Card standings. During Tuesday’s home victory, 3B Alex Bregman walked it off in the bottom of the ninth for the Cubs. Bregman’s RBI single scored Carson Kelly with the winning run. MVP candidate Pete Crow-Armstrong homered and drew a pair of walks for the Cubs (74-53), who moved to 38-26 at home.
Thirty-three year old righty Clay Holmes (5-5 2.56 ERA) will head to the hill for the Cubs in this contest. Holmes, who was acquired in a trade deadline deal with the Mets, has allowed just four long balls and sports a sparkling 1.07 WHIP across 63 plus frames.
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White Sox vs Cubs Pick
Chicago SS Dansby Swanson was placed on the 10-day injured list with an oblique issue and could be sidelined until the middle of next month. Through 125 games, the White Sox rank 9th in OPS and 8th in runs scored. For the season, the Cubs rank 3rd in OPS and 2nd in runs scored. Take the under. Final Score Prediction, Chicago Cubs win 4-3.
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