Chicago White Sox vs Cleveland Guardians Picks and Predictions for Friday, September 12, 2025

By: David Anicetti Published 09/12/2025, 12:05 AM ET

White Sox vs Guardians Game Information

The Chicago White Sox play the opening game of a three-game series on the road Friday versus the Cleveland Guardians. The first pitch is scheduled for 7:10 PM ET. Chicago enters at 56-90 (25-47 away) while Cleveland is 74-71 (37-34 home). The listed starters are lefty Martin Pérez for the White Sox and righty Tanner Bibee for the Guardians. Chicago won two of three in Detroit, while Cleveland won four of its last five with three one-run victories. Be ready for the end of the season with our free MLB Picks.

Chicago White Sox Preview

The White Sox have a slash line of .236/.305/.379 with 150 homers, and Lenyn Sosa has been the bright spot at .265 with team highs in homers (20) and RBI (67). Miguel Vargas has a team-high .314 on-base percentage, and catcher Kyle Teel has produced well at the plate of late, but Chicago’s scoring continues to be below average as runners are often stranded on base.

The pitching side offers some optimism: Pérez has a respectable 3.15 ERA and 1.07 WHIP over 45.2 innings, limiting hard contact and keeping the ball in the yard (4 home runs allowed). If Perez can prevent Cleveland’s best hitter, José Ramírez, from doing any damage and keep contact hitter Steven Kwan off base, Chicago could have a chance.

Cleveland Guardians Preview

Cleveland’s winning formula has been timely hitting supported by steadier run prevention over the last week. The Guardians’ season slash line is .225/.297/.370, and Ramírez continues to carry the offense with a .287 average, .361 on-base percentage, 28 homers, and 76 RBI, while Kwan’s 154 hits lead the club. Ramirez and Kwan are essential pieces if Cleveland hopes to win on Friday and battle for a wild card spot in the American League.

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The pitching staff has a 3.87 ERA and 1.30 WHIP, and Bibee’s strikeout-to-walk ratio (139 K, 50 BB) is solid. Cleveland’s bullpen stats have been steadier than Chicago’s (team bullpen ERA advantage). With the Guardians 4-1 in the last five, having a solid starter on the mound, and better results from the bullpen gives the Guardians a much better chance to come out on top.

Chicago White Sox vs Cleveland Guardians Prediction

Cleveland’s recent one-run wins show a club comfortable in close games, and Bibee’s overall performance on the mound will benefit the Guardians through the middle innings. Chicago’s Pérez has been solid, but Chicago’s offense hasn’t been as productive as Cleveland’s. Final Score Prediction: Cleveland Guardians win 5-3.