Chicago White Sox vs. Cleveland Guardians Picks and Predictions for Sunday, September 14, 2025

By: David Anicetti Published 09/14/2025, 12:05 AM ET

White Sox vs Guardians Game Information

The Chicago White Sox complete a three-game series on the road Sunday versus the Cleveland Guardians at Progressive Field with the first pitch at 1:40 PM ET on MLB.TV. The Chicago White Sox are 57–91 (25–48 Away) and the Cleveland Guardians are 76–71 (39–34 Home). The starting pitchers will be right-hander Yoendrys Gómez for Chicago and right-hander Slade Cecconi for Cleveland. The way to win is by using our free MLB picks.

Chicago White Sox Preview

Chicago is last in the American League Central, 27 games behind first place, and is the first team in the AL to be eliminated from postseason contention. Chicago has struggled all season at the plate (.235 AVG, 597 runs scored). Lenyn Sosa leads the White Sox with 20 home runs and 67 RBI but there isn’t much help around him. The White Sox have been especially weak on the road (25–48).

On the mound, the White Sox will have Yoendrys Gómez, who has had control issues (26 walks in 46 innings) and a 5.05 ERA. The White Sox need better control from Gomez, as Chicago’s bullpen has also struggled, and the further Gomez can go, the better.

Cleveland Guardians Preview

Cleveland trails first place in the American League Central by 7.5 games and is 3.5 games behind the 3rd and final AL wild card spot. Cleveland also struggles at the plate (.225 avg, 574 runs), but they have two reliable bats: José Ramírez with 28 home runs and a .283 batting average, and Steven Kwan with 155 hits and a .334 on-base percentage. Those two give the Guardians more steady production at the plate than Chicago.

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On the mound, Slade Cecconi has not been overpowering but has performed well over the last few starts. The right-hander is 6–6 with a 4.45 ERA and 1.25 WHIP. Cecconi has allowed too many homers, but since Chicago does not have the power at the plate to take advantage of the long ball, that should not be a problem on Sunday for the Guardians.

Chicago White Sox vs Cleveland Guardians Prediction

Neither Chicago nor Cleveland has performed well at the plate; therefore, the big difference in this matchup will be on the mound, where the Guardians have a big advantage with Cecconi over Gomez. Cleveland will produce enough runs against Gomez, while Chicago will struggle versus Ceconni, resulting in a victory at home for the Guardians to close out this series. Final Score Prediction: Cleveland Guardians win 7-3.