Chicago White Sox vs Minnesota Twins Picks and Prediction for September 4 2025

By: Cameron Ross Published 09/04/2025, 12:00 AM ET

White Sox Preview

The Chicago White Sox stay on the road Thursday night, where they play another game in Minnesota against the Minnesota Twins. Chicago is the worst team in the American League, nearly 40 games below .500, coming into this game on a three-game winning streak after winning the first two games in this matchup. Chicago has a .234 batting average this season, having scored 554 runs on 1,085 hits. The Chicago power has been shockingly strong with 142 home runs and a .376 slugging percentage. The Chicago pitching has been the team's biggest weakness, with a 4.22 team ERA. Stay in the action with our MLB Picks.

Davis Martin got the start and took the win for Chicago in their last outing, giving up three runs on six hits across 6 innings of work. The Chicago bullpen did the job, allowing no runs on one hit over the final three innings to seal the victory. Andrew Benintendi led the way for the Chicago offense in their last outing with four hits and five at-bats to drive in five total runs.

Twins Preview

The Minnesota Twins stay at home Thursday night, well below .500, having lost three of the last four. Offensively, Minnesota has been lackluster all season, with a .238 batting average. The Twins have scored 581 runs on 1098 hits. The Minnesota pitching has been the team's biggest issue, with a 4.51 team ERA, and Minnesota has allowed 30 total runs over its last three losses.

Simeon Woods Richardson got the start from Minnesota in their last outing, giving up three runs on two hits across 5 innings of work. Thomas Hatch came in relief and took the loss after giving up six runs on eight hits across only two innings. The rest of the Minnesota bullpen struggled as well, giving up three runs on three hits over the final two innings of the game. Minnesota got a mediocre offensive attack last time out with seven hits in 32 at-bats as three different players drove in one run each.

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White Sox vs Twins Betting Trends

The total has gone OVER in 6 of Chicago White Sox's last 8 games.
Chicago White Sox is 5-1 SU in its last 6 games against Minnesota.
The total has gone OVER in 8 of Minnesota's last 8 games.
Minnesota is 5-13 SU in its last 18 games.

White Sox vs Twins Pick

Both teams have been lackluster this season as each of below .500 overall. Despite the struggles in the first few games of the series look for Minnesota to bounce back in the series closer Thursday night. Take the Twins to do the work on their home field to get a win against the worst team in the American League. Final Score Prediction, Minnesota Twins win 6-2.