Cincinnati Reds vs Arizona Diamondbacks Picks and Predictions for Saturday, August 22nd, 2026

By: Cameron Ross Published 08/22/2026, 12:55 AM ET

Reds vs Diamondbacks Game Information

The Cincinnati Reds stay on the road Saturday night with another game inside Chase Field in Phoenix, AZ, at 8:10 PM against the Arizona Diamondbacks. Cincinnati is several games below .500 coming into this matchup and is currently the worst team in the National League Central. The Arizona Diamondbacks are a few games above .500 in the middle of the National League West coming into Saturday night. For more MLB action, see our MLB Picks.

Reds Preview

The Cincinnati offense has been bad this season, with a .226 batting average and has scored 523 runs on 958 hits. Cincinnati has a .305 OBP and a .390 team slugging percentage. Cincinnati's pitching has been the team's biggest issue, with a 4.47 team ERA. Elly De La Cruz leads the Reds offense this season with a .259 batting average. Sal Stewart also has a .259 batting average and leads the team with 27 home runs and 96 RBIs.

Diamondbacks Preview

The Arizona Diamondbacks offense has a .243 batting average, and Arizona has scored 579 runs on 1,044 hits. Arizona has a .316 OBP and a .398 team slugging percentage. Arizona's pitching has been solid enough, with a 4.18 team ERA. Gabriel Moreno leads Arizona this season with a .307 batting average. Ketel Marte has a .249 batting average, leads the team with 21 home runs, and 67 RBI's.

Reds vs Diamondbacks Pitching Matchup

Rhett Lowder will take the mound Saturday for Cincinnati. Lowder is 4-8 this year with a 5.17 ERA and a 1.49 WHIP across 101 innings. Michael Soroka will counter for Arizona. Soroka is 8-3 with a 2.93 ERA in 92 innings of work.

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Reds vs Diamondbacks Pick

Arizona has a substantial pitching advantage with Soroka on the mound and has played much better baseball than Cincinnati this season. The Diamondbacks should contain the Reds early before their offense creates separation against Lowder, leading to another home win.

Pick: Arizona Diamondbacks -163
Secondary: Over 8
Lean: Gabriel Moreno Over 1.5 Bases

Final Score Prediction: Arizona Diamondbacks win 7-3.

Game Written Before completion of the game on Friday.