Cleveland Guardians vs Detroit Tigers Picks and Prediction for Thursday May 21 2026
Guardians Preview
The Thursday MLB schedule will get underway with a matinee between the Cleveland Guardians and the Detroit Tigers from Comerica Park. Be ready for the baseball season with all of our MLB predictions. The Guardians (29-22) are riding a five-game winning streak and hold a three-game lead over Chicago for AL Central Division supremacy. Last night, OF Angel Martinez delivered an RBI triple and scored a run in the tenth inning to lift Cleveland to a 3-2 road victory against Detroit.
Twenty-six year old left-hander Joey Cantillo (3-1 3.40 ERA) will head to the hill for the Guardians in this contest. Cleveland has won Cantillo’s previous four starts and he has allowed nine runs over his last 20 innings.
Tigers Preview
The Detroit Tigers are looking to snap a five-game losing streak and have plummeted into the AL Central Division cellar. During Wednesday’s home loss, Detroit batters managed just five hits and left six runners on base. OF Zach McKinstry went 2-for-4 and drove in a run for the Tigers (20-30), who fell to 13-11 at home.
The Tigers will counter with 2018 number one overall draft pick Casey Mize (2-2 2.43 ERA) in the series finale. Through 37 innings of work, Mize has limited opponents to two long balls and struck out 39 batters while posting a sparkling 1.05 WHIP.
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Guardians vs Tigers Pick
Detroit 2B Gleyber Torres (oblique) is on the 10-day injured list and not ready to begin a rehab assignment. Through 51 games, Cleveland ranks 14th in OPS and 10th in runs scored. For the season, Detroit ranks 20th in OPS and 26th in runs scored. Take the Guardians to win on the road. Final Score Prediction, Cleveland Guardians win 4-3.
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