Cleveland Guardians vs Detroit Tigers Picks and Prediction for Thursday September 18 2025

By: Eddie Kline Published 09/18/2025, 12:25 AM ET

Guardians Preview

The Thursday MLB schedule will get underway with a matinee between the Cleveland Guardians and the Detroit Tigers from Comerica Park. Be ready for the baseball season with all of our MLB predictions. The Guardians (80-71) are riding a six-game winning streak and trail Boston by two games in the race for the final AL Wild Card spot. Last night, SP Gavin Williams (11-5) struck out nine batters and lasted five innings to lead Cleveland to a 4-0 road victory against Detroit.

Twenty-six year old righty Tanner Bibee (10-11 4.44 ERA) will take the mound for the Guardians in this matchup. In his last start, Bibee went the distance and retired ten batters by strikes during a 4-0 home victory versus Chicago.

Tigers Preview

The Detroit Tigers have dropped seven of their previous 11 games and hold a 4.5 game lead over Cleveland for the top spot in the AL Central Division. During Wednesday’s home loss, Detroit batters went 0-for-8 with runners in scoring position and left eight men on base. SP Jack Flaherty (8-14) allowed one run in five innings and took the loss for the Tigers (85-67), who fell to 46-31 at home.

The Tigers will counter with AL Cy Young Award frontrunner Tarik Skubal (13-5 2.26 ERA) in the series finale. Through 183 plus innings, Skubal has fanned 224 batters and leads the majors with a 0.86 WHIP.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers

Subscribe Now

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Picks And Parlays may use third-party services to process my data.

Guardians vs Tigers Pick

Detroit OF Matt Vierling has been pulled from his rehab assignment with soreness in his left oblique. Through 151 games, Cleveland ranks 29th in OPS and 27th in runs scored. For the season, Detroit ranks 12th in OPS and 9th in runs scored. Take the under. Final Score Prediction, Detroit Tigers win 4-1.

Never Tried Picks and Parlays? Now Is Your Chance

  • Get your first daily picks package for ONLY $1 using coupon code BUCK
  • If the pick loses, we credit your account with 3 Flex Picks
  • If the pick wins, we still give you 1 Flex Pick on the house
  • Win or lose, you walk away ahead. One dollar. No catch.
Onyx Odds

Spend $10 Get 200 in Bonus Picks

Show Bonus Code
Claim Bonus
Signup Promo Recommended Onyx Odds Bonus
Can be redeemed Yes
betr

$200 in No Sweat Entries + A Free Pick

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer
Min. Purchase $10
Requirement $200 Betr Bucks maximum per user ($100 from each Qualifying Entry token)
Playthrough 1x Bonus
Can be redeemed Yes
Thrillzz

Get 100% on any coins purchase up to $100

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer Thrillzz Bonus
Can be redeemed Yes
Video: Today's MLB BEST Bets: Brewers vs Padres + Royals vs Dodgers Picks and Predictions
Today's MLB BEST Bets: Brewers vs Padres + Royals vs Dodgers Picks and Predictions
Video: Daily Profit: Can The Seahawks REPEAT?? NFC West Betting Preview
Daily Profit: Can The Seahawks REPEAT?? NFC West Betting Preview
logo

If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL). Gambling problem? Call 1-800-GAMBLER (MI/NJ/PA/WV/WY), 1-800-9-WITH-IT (IN), 1-800-522-4700 (CO), 1-800-BETS OFF (IA), 1-888-532-3500 (VA), 1-800-NEXT STEP (AZ), or call/text TN REDLINE 1-800-889-9789 (TN). 21+ (18+ WY). AZ/CO/IL/IN/IA/MI/NJ/PA/TN/VA/WV/WY only. Eligibility restrictions apply. T&C's Apply. Void where prohibited. If you click on a link on this site which takes you to a bookmaker or casino and you subsequently open an account, Pick and Parlays may receive a commission. Bets placed are the responsibility of the bettor.

Copyright Β© 2026 Picks and Parlays. All rights reserved.

The sports news and information contained at this site is for entertainment purposes only. Any use of this information in violation of laws whether they are federal, state and/or local is prohibited. Picks and Parlays is the nation's premier resource for sports betting and handicapping information.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Special Offer
Spend $10 Get 200 in Bonus Picks
Play now T&Cs apply, 18+