Cleveland Guardians vs Minnesota Twins Picks and Predictions for Saturday September 20 2025

By: Jeremy O'Quinn Published 09/20/2025, 12:50 AM ET

Guardians Preview

The Cleveland Guardians are heading to Target Field on Saturday, where they will take on the Minnesota Twins. Get the rest of our free MLB picks here! The Guardians currently sit at 81-70 as they enter this matchup, keeping themselves in the heart of the AL Wild Card chase. Slade Cecconi will be the starting pitcher for Cleveland in this game, he comes in with a 6-6 record and a 4.39 ERA, with a WHIP around 1.22. The Guardiansโ€™ lineup has been steady all season, hitting .256 as a team while averaging 9.0 hits and 4.5 runs per game.

Twins Preview

The Minnesota Twins currently sit at 65-86 this season, a year where theyโ€™ve struggled to find consistency both at the plate and on the mound. Theyโ€™ll counter with Bailey Ober, who enters with a 5-8 record and a 5.17 ERA, carrying a WHIP near 1.31. Offensively, Minnesota has been streaky, hitting .242 as a team and averaging 8.5 hits and 4.3 runs per game. The Twinsโ€™ bullpen has had its share of difficulties, as theyโ€™ve allowed nearly 9.1 hits and close to 5 runs per game.

Guardians vs Twins Pick

Cleveland heads into this game on a staggering seven game win streak, while the Twins have dropped two straight games. Expect the Guardians to extend their win streak here, as Cecconi gets the job done. Final score prediction, Guardians win 5-3 and cover the -1.5 spread.

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