Cleveland Guardians vs Minnesota Twins Picks and Predictions for Sunday, September 21, 2025

By: David Anicetti Published 09/21/2025, 12:25 AM ET

The Cleveland Guardians visit the Minnesota Twins on Sunday at Target Field at 2:10 PM ET on MLB.TV. Cleveland has won five straight, including a 6–2 win here on Friday, and is second in the AL Central. Minnesota has dropped four of its last five and is fourth in the AL Central. Cleveland trails the final AL wild card by 1.5 games with 9 games remaining, and Minnesota has been eliminated from playoff contention. Score plenty of runs with our MLB previews.

Cleveland Guardians Preview

Cleveland is 82–71 and 41–37 on the road. Jose Ramirez sets the tone with a .282 average, 29 home runs, and 80 RBI, while Steven Kwan has made steady contact with 161 hits. The Guardians have hit 157 homers, but the Guardians are productive, stringing together hits. Overall, the Cleveland slash line is .226/.297/.372.

Lefty Joey Cantillo starts on the mound and has a 5–3 mark with a 3.27 ERA and 1.30 WHIP over 85.1 innings. The strikeout (95 K) has helped Cantillo avoid big innings, and he has kept the ball in the park (9 HR allowed). Cleveland’s pitching has been a strong point with a 3.74 team ERA and 1.28 WHIP.

Minnesota Twins Preview

Minnesota comes in 66–87 with a 37–41 home record. Byron Buxton leads with 31 home runs, 76 RBI, and a .268 average. Support comes from Trevor Larnach and Brooks Lee, while Ryan Jeffers has a strong on-base percentage. Team totals are .240/.313/.399 with 182 homers and 655 runs. The bats can be productive for Minnesota, but of late the Twins have left too many runners stranded on base..

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Simeon Woods Richardson goes for the Twins with a record of 7–4, a 4.31 ERA, and 1.36 WHIP across 100.1 innings. He has 95 strikeouts but has been touched by the long ball at times (16 homers). Minnesota’s staff ERA sits at 4.66 with a 1.34 WHIP, which has hurt the Twins all season. Minnesota’s bullpen has struggled of late, making it important that Woods Richardson reaches the seventh inning or beyond.

Cleveland Guardians vs Minnesota Twins Prediction

Cleveland is playing better, has the steadier pitching staff, and a starter who can limit damage. Minnesota has power, but recent results point to problems on the mound, both with starting pitching and the bullpen. With Cantillo’s strikeouts and Cleveland’s better overall pitching staff, the edge leans to the Guardians in a low-scoring game.