Colorado Rockies vs Arizona Diamondbacks Picks and Predictions for Thursday, May 21, 2026

By: Cameron Ross Published 05/21/2026, 12:20 AM ET

Rockies vs Diamondbacks Game Information

The Colorado Rockies will be on the road Thursday night for game 1 of 4 in Phoenix, AZ, inside Chase Field at 9:40 PM against the Arizona Diamondbacks. Colorado comes into this game struggling with 19 wins and 31 losses on the year, having lost 3 of the last 4, including 2 in a row after a 1-run loss against the Texas Rangers. The Arizona Diamondbacks stay home Thursday night with 25 wins and 23 losses on a 4-game winning streak after sweeping the San Francisco Giants. Stay in the news with our MLB Picks.

Rockies Preview

Offensively, Colorado has been solid this season, with a .245 batting average. The Rockies have scored 206 runs on 404 hits. Colorado has a .313 OBP and a .388 slugging percentage. The Colorado pitching has been bad this season, with a 5.04 team ERA. Troy Johnston leads the Colorado offense this season with a .324 batting average. Mickey Moniak has a .284 batting average, along with a team-leading 12 home runs and 28 RBIs.

Diamondbacks Preview

The Arizona offense has carried the team this season with a .245 batting average. The Diamondbacks have scored 215 runs on 384 hits this season. Arizona has a .311 OBP and a .403 team slugging percentage. The Arizona pitching staff has been shaky this season, with a 4.30 team ERA, but the Diamondbacks have given up 14 runs across their last 4 victories. Ildemaro Vargas leads the Arizona offense this season with a .331 batting average and 32 RBI's. Nolan Arenado has a .278 batting average to go along with the team-leading 7 home runs.

Rockies vs Diamondbacks Pitching Matchup

Tomoyuki Sugano will be on the mound Thursday night for the Rockies, looking to improve his season. Sugano is 4-3 with a 4.02 ERA this year through 47 innings of work. Eduardo Rodriguez will take the mound Thursday for Arizona, looking to keep rolling. Rodriguez is 4-1 this season with a 2.53 ERA through 53.1 innings of action.

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Rockies vs Diamondbacks Pick

Both teams have had their issues thus far this season, but Arizona is the better team in this matchup. The Diamondbacks are playing great baseball as of late and will thrive with an elite pitcher on the mound. Look for Arizona Thursday night to close this series with another victory against a lackluster Colorado team as the Diamondbacks continue to climb the standings in the National League West.

Pick: Arizona Diamondbacks
Secondary: Over
Lean: Ildemaro Vargas Over .5 RBIs

Final Score Prediction: Arizona Diamondbacks win 9-5.