Colorado Rockies vs San Diego Padres Picks and Predictions for Friday, September 12, 2025

By: Cameron Ross Published 09/12/2025, 12:30 AM ET

Rockies vs Padres Game Information

The Colorado Rockies remain on the road Friday for game two of four in San Diego against the Padres. Colorado is one of the worst teams in baseball and the worst in the National League coming into this matchup more than 60 games below .500 on the year. The San Diego Padres are currently the second-best team in the National League West in pursuit of a playoff berth, having won three of the last five overall. Stay in the action with our MLB Picks.

Rockies Preview

Colorado has been a bottom-feeder on both sides of the plate this season, with a .239 batting average. The Rockies have scored only 545 runs on 1168 hits. Colorado has some of the worst pitching in the league with a 6.01 team ERA, and the Rockies have walked 504 batters this season.

Padres Preview

The San Diego Padres have been one of the better teams in baseball this season on both sides of the plate. San Diego has a .251 batting average and has scored 617 runs on 1226 hits. The San Diego power has been solid enough as well, with 128 home runs and a .386 team slugging percentage. San Diego's biggest strength this season has been in their bullpen with a 3.65 team ERA.

Rockies vs Padres Pitching Matchup

Tanner Gordon will take the mound for Colorado Friday night with five wins and six losses and a 6.60 ERA across 60 innings of work. Dylan Cease will counter for San Diego with seven wins and 11 losses and a 4.71 ERA across 151 innings this season.

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Rockies vs Padres Pick

San Diego needs wins and will get one Friday night. Look for the Padres to dominate the worst team in the National League, start to finish, in this game. Take the Padres to do enough to get the victory at home against a terrible Colorado team.

Pick: San Diego Padres

Secondary: Over

Final Score Prediction: San Diego Padres win and cover 9-2.