Detroit Tigers vs Boston Red Sox Picks and Predictions for Friday, September 26, 2025

By: David Anicetti Published 09/26/2025, 12:05 AM ET

The Detroit Tigers visit the Boston Red Sox on Friday at Fenway Park with the first pitch at 7:10 PM ET on Apple TV+. Detroit lost 5–1 at Cleveland on Wednesday and is 85–73, second in the AL Central. Boston won 7–1 at Toronto on Wednesday and is 87–71, third in the AL East. Detroit currently holds the third and final AL wild card, while Boston is holding the second with just four games remaining. Step up to the plate with our MLB free picks.

Detroit Tigers Preview

The Tigers have dropped five in a row and need to bounce back to stay alive in the Wild Card race. The Tigers’ pitching has been steady most of the season, with a 3.97 ERA and 1.25 WHIP, holding opponents to a .242 batting average. That group has kept them in games even when the offense has had problems scoring runs.

Riley Greene continues to drive the lineup with 35 home runs and 110 RBI, while Spencer Torkelson has added 31 homers. Gleyber Torres gives Detroit another strong option with his ability to get on base at a .363 clip. The Tigers as a team hit .247 with a .316 on-base percentage and .415 slugging percentage. To match Boston at Fenway, Detroit will need runners on base in front of its power hitters and fewer strikeouts from the middle of the order.

Boston Red Sox Preview

The Red Sox have won three of their last four and are closing strong at Fenway, where they are 46–32 this season. The pitching staff has a 3.73 ERA, and the bullpen has held late leads over the past week. At home, Boston has been much tougher to beat, using extra base hits to break open tight games.

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Offensively, Trevor Story leads with 25 homers and 95 RBI, while Jarren Duran has a team-best .333 on-base percentage and speed at the top of the lineup. Alex Bregman and Wilyer Abreu add more punch. The Red Sox, as a team, are hitting .255 with a .325 on-base percentage and a .423 slugging percentage, numbers that give them the advantage against most teams at home.

Detroit Tigers vs Boston Red Sox Prediction

Boston’s recent wins, deeper lineup, and strong home record give the Red Sox the advantage at Fenway on Friday against a struggling Tigers’ team. Detroit has the power to keep it close, but Boston’s ability to string hits together at Fenway should decide the matchup. Final Score Prediction: Boston Red Sox win 5–3.