Detroit Tigers vs Cleveland Guardians Picks and Prediction for Tuesday September 23 2025
Tigers Preview
AL Central Division rivals will square off on Tuesday night, when the Detroit Tigers invade Progressive Field to take on the Detroit Tigers. Be ready for the baseball season with all of our MLB predictions. The Tigers (85-71) are looking to snap a six-game losing streak and are clinging to a one-game lead over the Guardians for first place. On Sunday, Detroit batters went 2-for-13 with runners in scoring position and left 13 men on base during a 6-2 home loss versus Atlanta.
Twenty-eight year old southpaw Tarik Skubal (13-5 2.23 ERA) is a lock to win his second consecutive American League Cy Young Award. Through 189 plus innings, Skubal has fanned 233 batters and leads the majors with a 0.88 WHIP.
Guardians Preview
The Cleveland Guardians have won nine of their last ten games and have moved into a tie with Houston for the final AL Wild Card spot. On Sunday, Cleveland OF Steven Kwan led off with his 11th home run during a 6-2 road loss against Minnesota. SP Joey Cantillo allowed one run in four plus innings and did not factor in the decision for the Guardians (84-72).
Cleveland manager Stephen Vogt will turn to right-hander Gavin Williams (11-5 3.06 ERA) on Tuesday. In his last start, Williams fired five shutout frames and struck out nine batters during a 4-0 road victory against Detroit.
Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Subscribe Now
Tigers vs Guardians Pick
Detroit OF Matt Vierling (oblique) has been pulled back from his rehab assignment and his status for the remainder of the season is uncertain. Through 156 games, Detroit ranks 12th in OPS and 9th in runs scored. For the season, Cleveland ranks 29th in OPS and 27th in runs scored. Take the Guardians to win at home. Final Score Prediction, Cleveland Guardians win 4-2.
Never Tried Picks and Parlays? Now Is Your Chance
- Get your first daily picks package for ONLY $1 using coupon code BUCK
- If the pick loses, we credit your account with 3 Flex Picks
- If the pick wins, we still give you 1 Flex Pick on the house
- Win or lose, you walk away ahead. One dollar. No catch.
Spend $10 Get 200 in Bonus Picks
$200 in No Sweat Entries + A Free Pick
Get 100% on any coins purchase up to $100
