Houston Astros at Los Angeles Angels Picks and Predictions for Sunday, September 28, 2025

By: David Anicetti Published 09/28/2025, 12:30 AM ET

The Houston Astros visit the Los Angeles Angels on Sunday at Angel Stadium at 3:07 PM ET on MLB.TV for the final game of the regular season. Houston lost 4–3 on Friday and is 85–75, second in the AL West with a 39–40 road record. Los Angeles won that game to move to 72–88, fourth in the AL West with a 39–40 home mark. Los Angeles has been eliminated from postseason contention, but Houston is battling for the third and final AL wild card. Build your bankroll by using our best bets.

Houston Astros Preview

The Astros have not announced a starter for Sunday’s final game of the regular season, as they want to see the results of Detroit and Boston on Saturday. The pitching staff has a 3.89 ERA and 1.23 WHIP, keeping them steady despite some recent losses. Houston has dropped four of its last five, but it can still qualify for the postseason with two wins and help from other clubs.

Jeremy Peña leads the team with a .304 average, while Jose Altuve has chipped in 26 home runs and 77 RBI. Christian Walker adds power with 25 homers and 86 RBI. As a team, Houston is hitting .250 with 174 home runs. The Astros have relied on a balance of solid hitting and pitching this season.

Los Angeles Angels Preview

The Angels will send left-hander Sam Aldegheri to the mound on Sunday. The southpaw has made just three appearances this season, after being called up from the minors, working nine innings with an 8.00 ERA. Aldegheri has allowed 13 hits and walked seven in that span.

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At the plate, Jo Adell has been the power bat with 37 homers and 97 RBI. Taylor Ward has also been strong with 36 home runs and a team-high 103 RBI. Mike Trout, who missed several games due to injury, is batting .230 with 25 home runs. As a group, the Angels are batting .226 with 225 homers but have struggled with strikeouts and low on-base numbers.

Houston Astros vs Los Angeles Angels Prediction

Houston is still fighting for a postseason berth, while Los Angeles is looking to close out the year and focus on next season. The Angels’ pitching is thin, and the Astros’ lineup should find chances to score. Houston’s bats will be the difference-maker in this final game of the regular season. Final Score Prediction: Houston Astros win 7-3.