Houston Astros vs Athletics Pick and Prediction for Wednesday, September 24, 2025

By: Ricky Mackenzie Published 09/24/2025, 01:07 AM ET

Astros Pitching Preview

Hunter Brown and the Astros will face Luis Severino and the Athletics in an AL West battle on Wednesday night. Get our free MLB Picks all season long! Brown enters with a stellar 2.30 ERA and 201 strikeouts over 180.1 innings, showing ace-level dominance all season. He’s been consistent both home and away and will look to set the tone early.

Athletics Pitching Preview

Luis Severino draws the start for Oakland and comes in with a 7-11 record and 4.72 ERA. He’s given up 119 strikeouts in 156.1 innings, but command has been an issue with 48 walks on the year. Against a disciplined Astros lineup, Severino will need to be sharp from the first pitch.

Astros Preview

Houston currently sits second in the AL West and is pushing hard for a postseason berth. Their offense has found rhythm recently, led by sluggers like Yordan Alvarez and Kyle Tucker. Even with shortstop Jeremy Peña listed day-to-day, the Astros have more than enough firepower to threaten early and often.

Athletics Preview

The Athletics, meanwhile, has little left to play for this season. That opens the door for Houston to be aggressive and play with urgency. With a clear pitching advantage and more at stake, the Astros should be expected to control majority of the game.

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Astros vs Athletics Pick

The Astros have superior pitching, deeper offense, and playoff motivation on their side. Expect Hunter Brown to dominate early, while Houston’s bats capitalize on Severino’s inconsistency. In what should be a statement game, the Astros are poised to come out strong and keep their hopes of winning the division alive. Final Score Prediction, Houston Astros win 6-2.