Houston Astros vs Athletics Picks and Prediction for Tuesday September 23 2025

By: Thomas Pemberton Published 09/23/2025, 12:35 AM ET
Pirates vs Astros prediction

The Houston Astros head to Sacramento on Tuesday to take on the Athletics in a three game series. Houston is a small road favorite and the total is set at 10 runs. The Astros seek payback after losing to the Athletics 7-1 in their last meeting back in late July. Be sure to check out our expert's MLB Free Picks.Β 

Houston Astros Preview

The Houston Astros are 2nd in the AL West with a 84-72 record. Houston is 5-5 over their last ten games and they carry a winning 38-37 road record. The Astros enter Sacramento riding a three game losing streak. Houston ranks 8th in the MLB averaging 8.5 hits per game.Jose Altuve leads Houston on the season with 26 home runs. Cristian Javier will make his 8th start on the mound for the Houston Astros. Javier is 2-3 on the season with 32.1 innings pitched. Javier has 30 strikeouts and carries a 4.45 ERA. Javier has pitched 6 innings in two straight starts. The Houston Astros carryΒ a 3.87 team ERA.

Athletics Preview

The Athletics are 4th in the AL West with a 73-83. The Athletics have won seven of their last ten games but have lost two straight games. The Athletics carry a 33-42 home field record. The Athletics are averaging 8.7 hits per game which is 5th best in the MLB. Brent Rooker leads the A's with 162 hits on the season. Jeffrey Springs will make the start on the hill for the Athletics. Springs is 10-11 on the season with 166 innings pitched. Springs has 135 strikeouts, 52 walks, and carries a 4.18 ERA. Springs pitched 4 innings in his last outing allowing 5 hits and 1 run. The A's carry a 4.72 team ERA.

Astros vs Athletics Free Picks & Prediction

Both the Astros and Athletics enter this series riding losing streaks. Houston has been outscored 17-7 over their last three games. While the Athletics have been outscored 13-0 over their last two games. Houston is the better team and show the best value.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers

Subscribe Now

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Picks And Parlays may use third-party services to process my data.

Never Tried Picks and Parlays? Now Is Your Chance

  • Get your first daily picks package for ONLY $1 using coupon code BUCK
  • If the pick loses, we credit your account with 3 Flex Picks
  • If the pick wins, we still give you 1 Flex Pick on the house
  • Win or lose, you walk away ahead. One dollar. No catch.
Onyx Odds

Spend $10 Get 200 in Bonus Picks

Show Bonus Code
Claim Bonus
Signup Promo Recommended Onyx Odds Bonus
Can be redeemed Yes
betr

$200 in No Sweat Entries + A Free Pick

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer
Min. Purchase $10
Requirement $200 Betr Bucks maximum per user ($100 from each Qualifying Entry token)
Playthrough 1x Bonus
Can be redeemed Yes
Thrillzz

Get 100% on any coins purchase up to $100

Show Bonus Code
Claim Bonus
Signup Promo Hot Offer Thrillzz Bonus
Can be redeemed Yes
Video: Today's MLB BEST Bets: Brewers vs Padres + Royals vs Dodgers Picks and Predictions
Today's MLB BEST Bets: Brewers vs Padres + Royals vs Dodgers Picks and Predictions
Video: Daily Profit: Can The Seahawks REPEAT?? NFC West Betting Preview
Daily Profit: Can The Seahawks REPEAT?? NFC West Betting Preview
  • Final Score Prediction: Houston Astros win 6-1.

Astros vs Athletics Best Pick:

  • Houston Astros -101
  • UNDER 10
logo

If you or someone you know has a gambling problem, crisis counseling and referral services can be accessed by calling 1-800-GAMBLER (1-800-426-2537) (IL). Gambling problem? Call 1-800-GAMBLER (MI/NJ/PA/WV/WY), 1-800-9-WITH-IT (IN), 1-800-522-4700 (CO), 1-800-BETS OFF (IA), 1-888-532-3500 (VA), 1-800-NEXT STEP (AZ), or call/text TN REDLINE 1-800-889-9789 (TN). 21+ (18+ WY). AZ/CO/IL/IN/IA/MI/NJ/PA/TN/VA/WV/WY only. Eligibility restrictions apply. T&C's Apply. Void where prohibited. If you click on a link on this site which takes you to a bookmaker or casino and you subsequently open an account, Pick and Parlays may receive a commission. Bets placed are the responsibility of the bettor.

Copyright Β© 2026 Picks and Parlays. All rights reserved.

The sports news and information contained at this site is for entertainment purposes only. Any use of this information in violation of laws whether they are federal, state and/or local is prohibited. Picks and Parlays is the nation's premier resource for sports betting and handicapping information.

Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Special Offer
Spend $10 Get 200 in Bonus Picks
Play now T&Cs apply, 18+