Los Angeles Dodgers vs Baltimore Orioles Picks and Predictions for Friday, September 5, 2025

By: David Anicetti Published 09/05/2025, 12:00 AM ET

Orioles vs Dodgers Game Information

The Baltimore Orioles play host to the Los Angeles Dodgers on Friday to start a three-game series at Camden Yards. The opening pitch is scheduled for 7:05 p.m. ET and can be seen on MASN. First meets last in this matchup as the Dodgers lead the National League West by 2.5 games with a record of 78-61, while Baltimore is in the American League East basement, with a record of 64-76, and on the verge of being eliminated from postseason contention. Make your MLB picks here.

Dodgers Preview

The Los Angeles Dodgers (78-61) have played poorly of late and need this series against the Baltimore Orioles to take a firmer grasp on first place in the National League West. Los Angeles has lost four of its last five games and needs to turn things around quickly with less than a month remaining in the regular season and holding only a 2.5-game lead.

Shohei Ohtani has been the most productive hitter for Los Angeles this season, leading the Dodgers with 46 home runs and 87 RBI. Andy Pages has been very productive as well, with 24 home runs and 78 RBIs, which are both second on the Dodgers. Los Angeles is second in home runs with 204 and second in RBI with 679. Los Angeles is second best in slugging percentage well third in runs scored, and fifth in on-base percentage.

Orioles Preview

The Baltimore Orioles are playing well of late, with three straight wins and four wins in the last five games, but are well back in the AL East. The Orioles beat the San Diego Padres on Wednesday night to complete a three-game sweep of San Diego. This series with Los Angeles will complete a nine-game road trip on the West Coast for the Orioles.

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Gunnar Henderson has 16 home runs and 61 RBI to lead Baltimore in both categories. Jackson Holliday is tied for the lead in home runs with 16 and is second in RBI with 52. Baltimore traded away much of its power at the deadline, sending Cedric Mullins, Ryan O’Hearn, Ramon Laureano, and Ramon Urias to other teams.

Dodgers vs Orioles Pitching Matchup

Tyler Glasnow gets the nod on the mound for LA on Friday. The right-hander is 1-3 with a 3.41 ERA, 81 strikeouts, and a 1.11 WHIP. Glasnow has performed below average over the last two starts, giving up six runs in 11 innings, with Los Angeles losing both games. Dean Kremer starts on the mound for the Orioles on Friday. The right-hander is 9-10 with a 4.52 ERA, 128 strikeouts, and 1.27 WHIP. Kremer has also struggled on the hill in each of the last two outings, giving up 13 runs in eight Innings with Baltimore losing both.

Dodgers vs Orioles Betting Odds

The current betting lines have LA at -175 and Baltimore at +180, with the over/under run total sitting at 9.5.

Dodgers vs Orioles Picks & Prediction

Baltimore is a solid choice for the runline, as the Orioles are 70-70 on the runline this season, while the Dodgers are 59-80, which is third from the bottom. The over in the run total is another solid choice, as both starting pitchers have struggled in each of their last two starts, and with Los Angeles second in both home runs and RBI, look for plenty of runs to cross the plate.