Milwaukee Brewers vs Chicago Cubs Picks and Prediction for Wednesday October 8 2025

By: Eddie Kline Published 10/08/2025, 12:10 AM ET

Brewers Preview

In Wednesday afternoon MLB playoff action, the Milwaukee Brewers will battle the Chicago Cubs from historic Wrigley Field. Be ready for the baseball season with all of our MLB predictions. The top-seeded Brewers (2-0) finished nine games above .500 on the road during the regular season and are looking to clinch their third postseason series victory since 1982. In Game Two, Andrew Vaughn and Jackson Chourio each hit three-run blasts to power Milwaukee to a 7-3 road triumph against Chicago.

Twenty-five year old righty Quinn Priester (13-3 3.32 ERA) will take the mound for the Brewers in this matchup. Milwaukee won 19 consecutive games started by Priester from May until late September, but he was roughed up for ten runs in 14 plus innings versus the Cubs this year.

Cubs Preview

The Chicago Cubs won 50 of 81 home games during the regular season and will need to win consecutive home games to force a winner-take-all Game Five in Milwaukee. During Tuesday’s road loss, Chicago scored all of their runs in the opening frame on a three-run bomb from Seiya Suzuki. SP Shota Imanaga (0-1) gave up four runs in two plus innings and took the loss for the Cubs.

Chicago manager Craig Counsell will turn to veteran right-hander Jameson Taillon (11-7 3.68 ERA) on Wednesday. In the wild card round, Taillon fired four shutout frames and fanned four batters during a 3-1 home victory versus San Diego.

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Brewers vs Cubs Pick

Milwaukee SP Brandon Woodruff is dealing with a lat injury and will not pitch in this series. Through 162 games, Milwaukee ranks 11th in OPS and 3rd in runs scored. For the season, Chicago ranks 7th in OPS and 5th in runs scored. With the wind expected to be blowing in from center field at 11 mph, the under is the play. Final Score Prediction, Chicago Cubs win 3-2.

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