Milwaukee Brewers vs Pittsburgh Pirates Picks and Predictions for Saturday September 6 2025
The Milwaukee Brewers visit the Pittsburgh Pirates Saturday afternoon at PNC Park with Milwaukee holding a firm grasp on first place in the NL Central. The Brewers have dropped three of their last five, while the Pirates have strung together three straight wins over the Dodgers. First pitch is scheduled for 4:40 PM ET, and bettors will be tuned in for our free MLB picks on this divisional clash.
Milwaukee Brewers Preview
Brandon Woodruff gets the nod on the mound for Milwaukee, bringing a 5-2 record and 3.69 ERA across 53.2 innings. Woodruff has 66 strikeouts to 14 walks, a 1.02 WHIP. Backing him is a balanced Brewers offense hitting .259 as a team with 152 home runs. Christian Yelich remains the most productive hitter, batting .268 with 27 homers and 92 RBI, while Sal Frelick leads the club with a .297 average and .360 OBP.
Milwaukee’s lineup has been an advantage. Brice Turang has 147 hits with a .291 average, and William Contreras continues to reach base at a .357 clip. Even with Rhys Hoskins sidelined, the Brewers have managed consistent production, scoring 717 runs on the year. The staff’s 3.63 ERA ranks among the better marks in baseball, supported by a bullpen that has allowed opponents to bat just .232.
Pittsburgh Pirates Preview
Mitch Keller counters for Pittsburgh, holding a 6-13 record with a 4.21 ERA over 156 innings. While his win-loss mark is below average, he’s tallied 132 strikeouts against 44 walks and remains in games into the sixth or seventh innings. Offensively, the Pirates have leaned on Bryan Reynolds, who leads with 70 RBI and a .246 average, while Oneil Cruz has supplied 19 home runs despite hitting just .202.
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Pittsburgh’s supporting bats have shown flashes but lack consistency. Andrew McCutchen carries a .342 OBP and remains a veteran presence, yet the team average sits at .234 with only 102 homers. On the mound, the staff ERA of 3.87 is respectable, though their offense’s 517 runs trail most in the NL. The Pirates’ recent sweep of the Dodgers gives the Pirates momentum.
Oddsmakers list Milwaukee as the favorite behind Woodruff. The Brewers are -140 on the moneyline, with a total of 7.5 runs. Given Pittsburgh’s light hitting and Milwaukee’s deeper lineup, the edge goes to the Brewers.
Prediction: Brewers 5, Pirates 3
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Pirates vs Brewers Best Picks:
- Brewers moneyline (-140) — Woodruff’s command gives Milwaukee the pitching edge.
- Over 7.5 runs (-105) — Pirates’ bats are improving, and both lineups can produce against the other's bullpen.
- Christian Yelich to record an RBI — he leads the Brewers with 92 and remains their top run producer.
