Minnesota Twins vs Chicago White Sox Picks and Prediction for Monday May 25 2026
Twins Preview
In Monday afternoon MLB action, the Minnesota Twins will travel to Rate Field to take on the Chicago White Sox. Be ready for the baseball season with all of our MLB predictions. The Twins (26-27) are riding a four-game winning streak and are five games out of first place in the AL Central Division standings. On Sunday, OF Trevor Larnach went 2-for-4 with an RBI and a pair of runs to spark Minnesota to a 6-5 road victory against Boston.
Twenty-six year old righty Zebby Matthews (1-1 1.38 ERA) will make his third start of the season for the Twins. Last time out, Matthews (6 IP) gave up a pair of runs and struck out six batters during a 2-1 home loss versus Minnesota.
White Sox Preview
The Chicago White Sox are four games above .500 at home and trail AL Central Division leading Cleveland by 4.5 games. On Sunday, Chicago 1B Miguel Vargas homered and scored twice during an 8-5 road loss against San Francisco. SP Noah Schultz (2-4) was tagged for six runs in four innings and took the loss for the White Sox (26-26).
The White Sox will counter with thirty-one year old southpaw Anthony Kay (3-1 4.27 ERA) on Monday. Chicago has won Kay’s previous three starts and he has allowed just four runs (3 ER) across his last 16 plus frames.
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Twins vs White Sox Pick
Minnesota C Ryan Jeffers will have surgery on his fractured left hamate bone and will miss the next 6-8 weeks. Through 53 games, Minnesota ranks 12th in OPS and 8th in runs scored. For the season, Chicago ranks 8th in OPS and 11th in runs scored. Take the Twins to win on the road. Final Score Prediction, Minnesota Twins win 5-3.
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