Minnesota Twins vs Chicago White Sox Picks and Prediction for Wednesday, September 3, 2025

By: Jake Allman Published 09/03/2025, 12:05 AM ET

Twins vs White Sox Game Info

The Minnesota Twins host the Chicago White Sox on Wednesday night at Target Field, first pitch set for 5:40 PM ET. Chicago enters at 50-88 overall and 20-46 on the road, while Minnesota sits at 62-75 and 35-33 at home. The White Sox took the opener of this series 6-5 on Monday. The pitching matchup features right-hander Yoendrys Gomez (3-2, 5.20 ERA, 1.54 WHIP) for Chicago against Zebby Matthews (4-4, 5.06 ERA, 1.48 WHIP) for Minnesota. Be ready for all the MLB action with our free MLB Picks.

White Sox Preview

The White Sox have shown slight improvement lately with back-to-back wins, including a one-run victory in the series opener. Despite an overall weak season, Chicago has managed some close contests behind clutch hitting from Lenyn Sosa, who leads with 18 home runs and 61 RBI while hitting .266. The White Sox lineup remains inconsistent, ranking near the bottom of the league with a .234 batting average and just 138 home runs.

Chicago’s pitching staff has been mediocre, holding a team ERA of 4.23 with 1,065 strikeouts. Gomez has struggled with command, issuing 24 walks in 36.1 innings, which has hurt his ability to work deep into games. The bullpen has also been thin with multiple relievers on the injured list, leaving manager Pedro Grifol with limited options late in games.

Twins Preview

Minnesota comes in with a better overall record but has been just as streaky, splitting its last four games. Byron Buxton continues to be the offensive engine with 29 homers, 72 RBI, and a strong .551 slugging percentage. As a team, the Twins hold a .238 batting average with 163 home runs, showing more pop than Chicago but still struggling for consistency.

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On the pitching side, Matthews has posted a 5.06 ERA across 58.2 innings, giving up 69 hits and 9 home runs. While he has struck out 70 batters, his 1.48 WHIP highlights his struggles with traffic on the bases. Minnesota’s staff as a whole carries a 4.47 ERA and 1.32 WHIP, but the injuries to multiple pitchers have stretched the rotation and bullpen thin.

White Sox vs Twins Pick

Pick: Minnesota Twins. Both teams are below .500 and have struggled, but the Twins have the stronger lineup with Buxton’s power and a bullpen that has held up slightly better than Chicago’s. Gomez’s control issues give Minnesota a better chance to string together runs at home. Final Score Prediction: Minnesota Twins 6, Chicago White Sox 4.