Minnesota Twins vs Cleveland Guardians Picks and Prediction for Sunday, May 10, 2026

By: Jake Allman Published 05/10/2026, 01:30 AM ET

The Minnesota Twins and Cleveland Guardians continue their series Sunday afternoon at Progressive Field. Cleveland picked up a 6-4 win in the opener and enters this matchup with momentum after winning three of the last four games. Bettors searching for free MLB picks should pay attention to the pitching matchup because both starters have been effective through the first month of the season. Elevate your MLB game with our top-notch MLB picks.

First pitch is scheduled for 1:40 p.m. ET in Cleveland, Ohio, with coverage on MLB.TV. The Guardians enter at 21-19 overall and 10-7 at home, while Minnesota is 16-23 and only 6-13 on the road. Cleveland also holds the edge in ESPN’s matchup predictor at 56.5%.

Twins Preview

Minnesota has struggled recently, allowing 28 runs during a three-game losing streak. The Twins still have productive hitters in the lineup, led by Byron Buxton with 12 home runs and Ryan Jeffers batting .300 with 23 RBI. Minnesota owns a .238 team batting average with 44 home runs, but the pitching staff has posted a 4.76 ERA and 1.39 WHIP this season.

Taj Bradley gets the ball for Minnesota and has been one of the team’s few bright spots. Bradley enters with a 4-1 record, 2.87 ERA, and 52 strikeouts across 47 innings. The right-hander has limited hitters to 39 hits while showing solid command throughout the season. Minnesota needs another strong outing because several bullpen arms remain on the injured list.

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Guardians Preview

Cleveland has played better baseball over the past week and continues getting balanced production offensively. Chase DeLauter has been excellent with a .306 average, six home runs, and 23 RBI, while Jose Ramirez remains a dangerous power bat in the middle of the order. The Guardians have also won seven of 14 day games this season and continue to play well at Progressive Field.

Gavin Williams has quietly been outstanding for Cleveland. Williams enters Sunday with a 5-2 record, 3.28 ERA, and 60 strikeouts in 49.1 innings. The Guardians staff also owns better overall numbers than Minnesota in ERA, WHIP, strikeouts, and opponent batting average. Cleveland’s bullpen has been more reliable lately, which could become the difference late in the game.