Minnesota Twins vs San Diego Padres Picks and Predictions for Saturday, August 22nd, 2026

By: Cameron Ross Published 08/22/2026, 01:00 AM ET

Twins vs Padres Game Information

The Minnesota Twins continue their road trip in San Diego Saturday night with another game inside Petco Park at 8:40 PM against the San Diego Padres. Minnesota is right around .500 this season, coming into Saturday currently in the mix for the top spot in the American League Central. The San Diego Padres are several games above .500 heading into this matchup right now in a battle for the second-place spot in the National League West. Stay in the loop with our MLB Picks.

Twins Preview

The Minnesota Twins offense has a .246 batting average this season and has scored 592 runs on 1062 hits. Minnesota has a .321 OBP they .406 team slugging percentage. Minnesota's pitching has been horrendous, with a 4.62 team ERA this season. Luke Keaschall leads Minnesota with a .272 batting average. Byron Buxton has a .256 batting average and leads the team with 25 home runs. Josh Bell has a. 258 batting average and leads Minnesota with 77 RBI's this season.

Padres Preview

The San Diego Padres offense has struggled this season with a .230 batting average, scoring 543 runs on 1001 hits. San Diego has a .315 OBP and a .389 team slugging percentage this season. Fernando Tatis Jr leads San Diego with a .280 batting average. Manny Machado has a .215 batting average and leads the team with 24 home runs and 71 RBI.

Twins vs Padres Pitching Matchup

Dean Kremer will start Saturday for Minnesota. Kremer is 2-4 this season with a 5.40 ERA across 53.1 innings. Casey Mize will counter for San Diego. Mize is 5-7 with a 3.18 ERA in 102 innings.

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Twins vs Padres Pick

San Diego has the stronger starting pitcher and has consistently played its best baseball at Petco Park. Kremer has struggled this year, and he will spark the San Diego bats. Look for San Diego to use its pitching and home-field advantage to get the win.

Pick: San Diego Padres -169
Secondary: Under 8
Lean: Fernando Tatis Jr. Over 1.5 Bases

Final Score Prediction: San Diego Padres win 4-1.

Game Written Before completion of the game on Friday.