MLB Best Bets Today - MLB Playoff Predictions for Every Game (Oct. 1, 2025)

By: Devin Erickson-Sheehy Published 10/01/2025, 08:05 AM ET

The MLB postseason is officially in full swing with Game 2 on tap across every Wildcard matchup. Picks & Parlays has MLB picks for every game this postseason, don't miss out!

Below, we break down our MLB best bets today, highlighting the strongest edges for October 1, 2025 while weaving in advanced trends, starter/bullpen numbers, and lineup considerations.

For those searching for MLB playoff picks or the best MLB bets today, these four wagers combine pitching analysis, offensive splits, and key postseason angles.

MLB Best Bets for October 1, 2025

Guardians/Tigers under 7 runs (-135, buy the half run)

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Padres moneyline (-104)
Red Sox/Yankees under 7.5 runs (-120)
Dodgers -1.5 (-125)

MLB Best Bet #1: Guardians vs. Tigers – Under 7 Runs

Game 1 was a pitcher’s clinic, ending 2-1 behind Tarik Skubal’s postseason-record 14 strikeouts. For Game 2, Detroit turns to Casey Mize (3.87 ERA), while Cleveland counters with Tanner Bibee, who has a sharper 3.22 ERA at home and has allowed less than one home run per nine innings.

Since the start of September , both lineups have been ice-cold. Detroit ranks 22nd in runs scored, while Cleveland sits 28th in home runs. With the Guardians’ bullpen carrying a top-two ERA (3.45), runs should once again come at a premium.

Buying the half run on the under 7 creates a stronger position in what projects as another low-scoring playoff battle between two struggling lineups.

Also see: Tigers vs Guardians prediction

Best MLB Bet #2: Padres on the Moneyline

It was a set back for the Padres yesterday as they were stymied by a superb Chicago bullpen. Even so, San Diego has momentum on its side entering the Wild Card, having surged in September with an improved bullpen and balanced lineup production.

The Cubs stumbled down the stretch, especially at Wrigley Field, where their offense posted bottom-five slugging numbers in September. The Padres’ postseason-tested roster, highlighted by veterans with playoff experience, gives them a clear edge when facing elimination. Dylan Cease gives them a favorable matchup on the hill and recent trends/metrics show solid value on San Diego at this price.

Also see: Padres vs Cubs prediction

MLB Playoff Pick #3: Red Sox vs. Yankees – Under 7.5 Runs

The storied rivalry added another riveting chapter last night with Boston narrowly escaping in Game 1.

We see another pitchers duel on tap for Game 2 with Carlos Rodon and Bryan Bello both offering strong support on the hill for their respective sides.

The Yankees’ staff ERA was among the league’s best in September, and Boston’s bullpen quietly ranked top-10 in WHIP, signaling fewer scoring chances on both sides.

Playoff tension, reliable starters, and bullpen depth all favor another under, with 7.5 providing a key buffer in what should be a tightly managed game.

Also see: Red Sox vs Yankees prediction

MLB Playoff Best Bet #4: Dodgers on the Run Line

The Dodgers entered this series as heavy favorites and proofed why, rolling to an easy Game 1 win.

Los Angeles owns a top-three offense and one of the deepest postseason rotations in baseball. Cincinnati’s young arms have talent but lack postseason polish, and their September splits (.223 team batting average) don’t inspire confidence.

Given the Dodgers’ history of handling lesser opponents in October, laying the run line is a sharp angle for a decisive home victory. Dodgers win and cover again, and advance to the NLDS.

Also see: Reds vs Dodgers prediction