New York Mets vs Chicago Cubs Picks and Predictions for Tuesday, September 23, 2025

By: David Anicetti Published 09/23/2025, 12:15 AM ET

The New York Mets visit the Chicago Cubs on Tuesday at Wrigley Field, starting at 7:40 PM ET on TBS. New York sits at 80–76, third in the NL East, and has dropped three of its last five, including two close ones to Washington. Chicago is 88–68, second in the NL Central, and has lost four straight in Cincinnati but remains strong at home with a 46–29 record. Chicago has clinched a postseason berth, while New York is fourth in the NL wild card race with only the top three qualifying. Score big with our free MLB predictions.

New York Mets Preview

David Peterson gets the start for the Mets. The left-hander is 9–6 with a 3.98 ERA and 1.34 WHIP over 167.1 innings. He has struck out 149, walked 63, and kept the ball in the park with only 11 homers allowed. Peterson must be on form and limit base runners against a Cubs team that is patient at the plate.

New York has a solid mix of power and speed at the plate. Juan Soto leads with 42 home runs and a .399 on-base percentage, while Pete Alonso adds 37 home runs and 122 RBI with a .274 average. Francisco Lindor tops the club with 166 hits. The Mets sit at .250 with 739 runs and 215 home runs, but have struggled on the road at 31–44.

Chicago Cubs Preview

Cade Horton starts for Chicago. The right-hander is 11–4 with a 2.66 ERA and 1.10 WHIP in 115.0 innings. He has 95 strikeouts, 33 walks, and only nine home runs allowed. Horton works ahead in counts and mixes pitches well, giving Chicago a strong performance most of the time.

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The Cubs’ lineup has been steady most of the year. Michael Busch leads with 30 home runs, Seiya Suzuki has 27 homers and 91 RBI, and Nico Hoerner sets the table for the power hitters with a .299 average and 171 hits. As a team, Chicago is batting .249 with 750 runs and 209 homers. Even after a rough series in Cincinnati, the Cubs remain a strong home team and have leaned on their pitching staff’s 3.82 ERA.

New York Mets vs Chicago Cubs Prediction

The pitching matchup points to a lower-scoring game. Peterson has been steady at limiting damage, but Horton’s sharper numbers and Chicago’s home record give the Cubs the slight advantage. If the Cubs can score early, Horton should carry the lead into the later innings and hand it off to a capable bullpen. Final Score Prediction: Chicago Cubs win 4-2.