New York Mets vs Chicago Cubs Picks and Predictions for Wednesday, September 24, 2025

By: David Anicetti Published 09/24/2025, 12:20 AM ET

The New York Mets visit the Chicago Cubs on Wednesday at Wrigley Field. The first pitch is scheduled for 8:00 PM ET on ESPN. The Mets are 80–76, 3rd in the NL East, and have lost three of their last five. The Cubs are 88–68, 2nd in the NL Central, and enter this matchup on a four-game losing streak. New York has dropped to fourth in the NL wild card race, with just the first three qualifying. Chicago has clinched a wild card berth in the NL. Be ready for the opening pitch with our MLB Picks.

New York Mets Preview

The Mets continue to battle for a wild card spot despite recent poor play. New York dropped two of three to Washington, scoring just five runs across the final two games. Jonah Tong will take the mound, making only his fifth major league start. The right-hander has shown he can make hitters miss with 21 strikeouts in 16.2 innings, but has a 5.94 ERA and seven walks.

At the plate, New York is powered by Juan Soto and Pete Alonso. Soto leads with 42 home runs, 104 RBIs, and a .399 on-base percentage, while Alonso has driven in 122 runs with 37 homers and a .274 average. Francisco Lindor continues to produce in the leadoff spot with 166 hits and 112 runs scored. Overall, the Mets have hit 215 home runs and are batting .250 as a team.

Chicago Cubs Preview

Chicago arrives after being swept in Cincinnati, scoring just two runs across the three-game series. Matthew Boyd gets the start, carrying a 13–8 record with a 3.20 ERA and 151 strikeouts in 174.1 innings. His command has been steady with just 41 walks, and he has been far more effective at Wrigley, where the Cubs have a 46–29 home record.

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Offensively, Nico Hoerner leads the club with a .299 average and 171 hits. Michael Busch has emerged as the power threat, hitting 30 home runs with 82 RBIs, while Seiya Suzuki has added 27 homers and a team-best 91 RBIs. The Cubs have scored 750 runs while batting .249 as a team, complementing a pitching staff that holds a 3.82 ERA.

New York Mets vs Chicago Cubs Prediction

Chicago holds the advantage on the mound with Boyd, and the Cubs’ lineup is deeper with Pete Crow-Armstrong, Michael Busch, and Seiya Suzuki, among others. New York’s offense has relied heavily on Soto and Alonso, but Tong’s control issues at times could be exposed by a Cubs team that is patient at the plate. Final Score Prediction: Chicago Cubs win 5-3.