New York Yankees vs Boston Red Sox Picks and Predictions for Saturday, September 13, 2025

By: David Anicetti Published 09/13/2025, 12:05 AM ET

Yankees vs Red Sox Preview

The New York Yankees play the second game of a three-game series on the road Saturday versus the Boston Red Sox at Fenway Park with the opening pitch at 2:10 PM ET, televised on MLB Network. New York comes in at 81–65 (37–34 away) and Boston is 81–66 (44–28 home). The matchup features Max Fried (16–5, 3.02 ERA, 1.10 WHIP) on the mound for the Yankees against Brayan Bello (11–6, 3.12 ERA, 1.21 WHIP). The Yankees have more power (249 homers) and a .455 slugging percentage, while the Red Sox have performed better on the mound with a 3.74 team ERA. The MLB season is close to wrapping up, so you better get all the best winning MLB picks before its over!

New York Yankees Preview

New York counts on solid pitching and star production at the plate. Starting pitcher Fried’s season has been steady across 176.0 innings with just 13 home runs allowed, and strong control, especially when ahead in the count, which is needed in the confines of Fenway Park. If Fried can work into the seventh, the Yankees’ staff-wide .232 opponent batting average works to New York’s advantage once the bullpen takes over.

The Yankees' main power supply comes from Aaron Judge, who has a slash line of .322/.443/.669 with 46 home runs and 100 RBI, and is helped by Cody Bellinger’s .277/.334/.500 solid season. New York’s recent form has been inconsistent, taking three of five with two close wins over Toronto and a nine-run effort against Detroit. Anthony Volpe is listed as day-to-day.

Boston Red Sox Preview

Boston has had success both at the plate and on the mound this season. Starter Bello has worked 152.2 innings, giving up only 14 home runs, and allows enough ground balls to work around runners on base. The Red Sox have an overall ERA of 3.74, which is 5th in baseball, and a bullpen ERA of 3.45, which is third best. If Boston reaches the late innings in front, odds are good the pen will keep New York’s hitters at bay.

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The Red Sox have scored runs through timely hits from several players. Trevor Story leads with 24 home runs and 91 RBI, while Jarren Duran has a .334 on-base percentage and 146 hits. The Red Sox have won three of their last five despite a one-run loss in Oakland, and have mixed power with clutch hits. Even with a couple of position players out injured, the lineup has plenty of depth.

Prediction New York Yankees vs Boston Red Sox

Boston will win. Boston starter Bello has performed well at home, the Red Sox have an overall better ERA, and Boston has a strong record at home. The power-heavy Yankees lineup will threaten each time up, but Boston’s pitching staff is playing well enough at this point to contain the bats.