New York Yankees vs Boston Red Sox Picks and Predictions for Wednesday April 22 2026
The New York Yankees and Boston Red Sox will square off at Fenway Park in Boston, Massachusetts on Wednesday, April 22, 2026, with first pitch scheduled for 6:45 PM and coverage available on MLB.TV, MLB Net, and Prime Video. The betting odds list the Yankees as a -136 favorite on the moneyline, while the Red Sox come in at +113. The total is set at 8 runs, with the over priced at -102 and the under at -118. On the run line, New York is -1.5 at +119, while Boston is +1.5 at -143. Make sure to check out free MLB picks.
Starting Pitchers Set for the Rivalry Clash
Max Fried takes the mound for New York with a 2-1 record, a 2.97 ERA, and an impressive 0.81 WHIP across 33.1 innings. He has allowed just 19 hits while striking out 23 and walking 8, giving up only 1 home run. Opposing him is Ranger Suarez for Boston, who enters with a 1-1 record, a 3.22 ERA, and a 1.07 WHIP over 22.1 innings. He has allowed 18 hits, recorded 15 strikeouts, walked 6, and surrendered 2 home runs.
Yankees Riding Strong Form into Boston
New York comes into this matchup with a 13-9 record and a 5-4 mark on the road. The Yankees have been playing well recently, recently winning over Kansas City in three straight games with scores of 7-0, 13-4, and 4-2. Prior to that, they recently lost to Los Angeles 11-4 but also picked up a 5-4 win in that same stretch. That recent run shows a team that has found rhythm offensively and has been able to stack wins together.
From a statistical standpoint, New York is hitting .218 with 110 runs, 155 hits, and 32 home runs. The Yankees have posted a .323 on-base percentage and a .410 slugging percentage. On the pitching side, they hold a 3.40 ERA and a 1.17 WHIP, while allowing opponents to hit .229. The staff has recorded 201 strikeouts with just 60 walks.
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A key strength for New York is its power production combined with efficient pitching. The 32 home runs stand out, and when paired with a 3.40 ERA and 1.17 WHIP, it highlights a team that can both generate runs and limit opponents effectively.
Red Sox Looking to Hold Their Ground at Home
Boston enters this contest with a 9-13 record and a 5-5 mark at home. The Red Sox recently won over Detroit 8-6 and have shown mixed results over their last five games. In that stretch, they also recently won over Detroit in extra innings and picked up a 9-5 win against Minnesota, while recently losing to Detroit in two games as well. That pattern reflects a team that has been competitive but has struggled to maintain consistency.
Offensively, Boston is hitting .233 with 89 runs, 171 hits, and 13 home runs. The Red Sox have posted a .318 on-base percentage and a .345 slugging percentage. On the pitching side, they carry a 4.42 ERA and a 1.33 WHIP, while allowing opponents to hit .241. Their staff has recorded 170 strikeouts and issued 81 walks.
One notable weakness for Boston is its pitching consistency. The higher ERA and WHIP compared to New York indicate that opponents have been able to create scoring opportunities, which can be difficult to overcome against a team that has shown power at the plate.
New York Yankees vs Boston Red Sox Picks and Prediction
New York Yankees vs Boston Red Sox Pick
Pick: New York Yankees Moneyline
New York enters this matchup with a clear advantage in both pitching efficiency and power production. The Yankees’ 3.40 ERA and 1.17 WHIP stand out against Boston’s higher numbers, and their 32 home runs highlight an ability to score quickly. With New York also coming off multiple recent wins and Boston showing inconsistency, the Yankees appear to have the stronger overall profile heading into this game.
New York Yankees vs Boston Red Sox Total Pick
Pick: Under 8
I’m leaning toward the under in this matchup because of the starting pitching and overall pitching numbers from New York. With a 3.40 ERA and a WHIP near 1.17, the Yankees have shown they can limit scoring opportunities. While Boston has had some offensive success, their overall production has been more modest. With both teams capable of stretches of controlled play, this game sets up as one where runs could stay under the total.
Final Score Prediction: New York Yankees 4 – Boston Red Sox 3
This prediction was written before the completion of game play on Tuesday.
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