Pittsburgh Pirates vs Arizona Diamondbacks Picks and Prediction for Tuesday May 5 2026

By: Kim Smith Published 05/05/2026, 01:15 AM ET

The Pittsburgh Pirates will face the Arizona Diamondbacks at Chase Field in Phoenix, Arizona, on Tuesday, May 5, 2026, with first pitch scheduled for 9:40 PM ET. The game will be available on MLB.TV, and game-time weather is expected to be 78 degrees. At the time of this writing the odds were not released. Be sure to check out free MLB picks for more insights on todayโ€™s action.

Starting Pitchers

Bubba Chandler will take the mound for Pittsburgh, entering with a 1-3 record, a 4.97 ERA, and a 1.48 WHIP across 29.0 innings pitched. He has allowed 23 hits while striking out 27 batters and issuing 20 walks, along with giving up five home runs. Opposing him will be Eduardo Rodriguez for Arizona, who comes in with a 2-0 record, a 3.03 ERA, and a 1.41 WHIP over 32.2 innings. He has allowed 30 hits while striking out 22 batters and issuing 16 walks, while surrendering four home runs.

Pittsburgh Riding Recent Momentum

The Pittsburgh Pirates enter this matchup with a 19-16 overall record and an 8-7 mark on the road. In their last five games, they recently won over Cincinnati in three consecutive contests by scores of 1-0, 17-7, and 9-1, while also recently lost to St. Louis in back-to-back games by scores of 10-5 and 5-4. This recent stretch reflects a team that has shown strong offensive output in wins while still dealing with some inconsistency.

From a statistical standpoint, Pittsburgh is batting .253 with 180 runs on 307 hits and 38 home runs. They have posted a .339 on-base percentage and a .393 slugging percentage. On the pitching side, the Pirates hold a 3.72 ERA with a 1.23 WHIP, allowing a .222 opponent batting average. Their staff has issued 131 walks while recording 330 strikeouts, demonstrating strong pitching performance.

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A key strength for Pittsburgh is their pitching staff, as reflected in their lower ERA, WHIP, and opponent batting average. Combined with their recent offensive performances, this gives them a balanced profile capable of competing in this matchup.

Arizona Looks to Rebound at Home

The Arizona Diamondbacks come into this contest with a 16-17 overall record and a 9-6 record at home. In their last five games, they recently lost to Chicago in three consecutive contests by scores of 8-4, 2-0, and 6-5, while also recently lost to Milwaukee in a 13-1 result. Their only recent win came in a 6-2 victory over Milwaukee, showing a team that has struggled to maintain momentum.

Offensively, Arizona is batting .247 with 150 runs on 272 hits and 34 home runs. They have recorded a .304 on-base percentage and a .412 slugging percentage. Their pitching staff carries a 5.07 ERA with a 1.41 WHIP, allowing a .260 opponent batting average. They have issued 116 walks and recorded 242 strikeouts, indicating challenges in run prevention.

A key weakness for Arizona is their pitching performance, particularly their higher ERA and WHIP compared to Pittsburgh. While their offense has shown the ability to generate runs, their inability to consistently limit opposing hitters has been a significant issue.

Pittsburgh Pirates vs Arizona Diamondbacks Picks and Prediction

Pittsburgh Pirates vs Arizona Diamondbacks Pick

  • Pick: Pittsburgh Pirates Moneyline

The Pirates enter this matchup with an advantage in overall pitching performance, as reflected in their lower ERA, WHIP, and opponent batting average. While Arizona has shown offensive potential, Pittsburghโ€™s ability to limit runs provides a more consistent foundation. Combined with their recent offensive success, the Pirates are well positioned to come out ahead.

Pittsburgh Pirates vs Arizona Diamondbacks Total Pick

  • Pick: Over 9.5

I am leaning toward the over in this matchup due to Arizonaโ€™s higher ERA and WHIP, which could allow Pittsburgh to generate scoring opportunities. At the same time, Arizonaโ€™s offense has shown the ability to produce runs, creating potential for both teams to contribute to the total. This combination suggests a game that could exceed the number.

Final Score Prediction: Pittsburgh Pirates 6 โ€“ Arizona Diamondbacks 4

This prediction was written before the completion of game play on Monday.

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