Pittsburgh Pirates vs Cincinnati Reds Picks and Prediction for Thursday September 25 2025
Pirates Preview
The Thursday MLB schedule will get underway with a matinee between the Pittsburgh Pirates and the Cincinnati Reds from the Great American Ball Park. Be ready for the baseball season with all of our MLB predictions. The Pirates (69-89) are riding a four-game winning streak and are relishing in their role as spoilers. Last night, 1B Spencer Horwitz went 3-for-5 and drove in three runs to lead Cincinnati to a 4-3 road victory against Cincinnati.
Rookie right-hander Braxton Ashcraft (4-3 2.62 ERA) will make his eighth career major league start for the Pirates. Through 65 plus innings, Ashcraft has limited the opposition to three long balls and has retired 66 batters by strikes.
Reds Preview
The Cincinnati Reds are eight games above .500 at home and trail New York by one full game for the final NL Wild Card spot. During Wednesday night’s home loss, Cincinnati batters went 1–for-10 with runners in scoring position and left 13 men on base. C Tyler Stephenson fell a triple short of the cycle in a losing effort for the Reds (80-78).
Cincinnati manager Terry Francona will give the nod to talented lefty Nick Lodolo (8-8 3.44 ERA) in the series finale. Last time out, Lodolo (4.2 IP) gave up four runs and fanned seven batters during a 7-4 home victory versus Chicago.
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Pirates vs Reds Pick
Cincinnati OF Austin Hays is dealing with back spasms and is listed as day-to-day. Through 158 games, Pittsburgh ranks 30th in OPS and 30th in runs scored. For the season, Cincinnati ranks 19th in OPS and 14th in runs scored. Take the Pirates to win on the road. Final Score Prediction, Pittsburgh Pirates win 5-3.
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