Pittsburgh Pirates vs Cincinnati Reds Picks and Predictions for Wednesday, September 24, 2025

By: David Anicetti Published 09/24/2025, 12:00 AM ET

The Pittsburgh Pirates visit the Cincinnati Reds on Wednesday at Great American Ball Park. The first pitch is at 6:40 PM ET on MLB.TV. The Pirates are 67–89 and 5th in the NL Central, coming off two straight wins over Oakland. The Reds are 80–76, 3rd in the NL Central, and enter on a five-game winning streak after sweeping the Cubs. Pittsburgh has been eliminated from postseason contention, while Cincinnati currently holds the third and final NL wild card, but only by a tiebreaker. Hit a home run and win the game with our free MLB picks.

Pirates vs Reds Team Stats Comparison

At the Plate

Pirates: .231 AVG, .305 OBP, .350 SLG, 561 runs, 112 HR

Reds: .245 AVG, .315 OBP, .392 SLG, 697 runs, 161 HR

Subscribe Now

I authorize Picks And Parlays to send me promotional emails

I understand that I can unsubscribe at any time. I have read and accepted the Terms & Conditions and Privacy Policy. I consent that Picks And Parlays may use third-party services to process my data.

Terms & Conditions

On the Mound

Pirates: 3.82 ERA, 1.22 WHIP, opponents hitting .236

Reds: 3.91 ERA, 1.23 WHIP, opponents hitting .235

Form

The Pirates have struggled on the road with a 23–52 record. Cincinnati has been reliable at home, posting a 44–34 mark. Pittsburgh has won back-to-back games but dropped seven of its last ten overall. The Reds are peaking at the right time, winning five straight and six of their last seven.

Probable Starters

Pittsburgh: Paul Skenes (10–10, 2.03 ERA, 0.96 WHIP, 209 Ks in 181.2 IP)

Cincinnati: Hunter Greene (7–4, 2.74 ERA, 0.92 WHIP, 125 Ks in 101.2 IP)

Both pitchers have excellent strikeout rates and low WHIPs, setting up a low-scoring matchup. Cincinnati’s better overall lineup gives them a slight advantage playing at home despite Pittsburgh’s ace Skenes being on the mound.

Pittsburgh Pirates vs Cincinnati Reds Prediction

The matchup will be a pitcher’s duel with limited scoring opportunities as long as the starting pitchers are on the mound. Cincinnati’s stronger lineup and current momentum will help overcome the talented right-hander Skenes of the Pirates. Final Score Prediction: Cincinnati Reds win 4-2.