Pittsburgh Pirates vs Washington Nationals Picks and Prediction for Friday September 12 2025
Pirates Preview
Nationals Park will play host to a Friday night MLB clash between the Pittsburgh Pirates and the Washington Nationals. Be ready for the baseball season with all of our MLB predictions. The Pirates (64-83) have dropped 50 of 72 road games and are trapped in the NL Central Division basement. On Thursday, Pittsburgh batters went 1-for-10 with runners in scoring position and left seven men on base during a 3-2 road loss against Baltimore.
Twenty-nine year old righty Mitch Keller (6-14 4.16 ERA) will head to the hill for the Pirates in this contest. In his last start, Keller (6.1 IP) gave up five hits and two runs during a 4-1 home loss versus Milwaukee.
Nationals Preview
The Washington Nationals have won seven of their last ten games and own the second worst record in the National League. Last night, Washington committed a pair of errors and struck out nine times during a 5-0 road loss against Miami. SP MacKenzie Gore (5-14) gave up two runs in five innings and took the loss for the Nationals (60-86), who fell to 31-44 on the road.
Rookie left-hander Andrew Alvarez (1-0 1.86 ERA) will make his third career major league start for the Nationals. Last time out, Alvarez allowed two runs and lasted four plus innings during a 6-3 road victory against Chicago.
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Nationals vs Pirates Pick
Washington C Keibert Ruiz (concussion) was pulled back from his rehab stint and his status to return is uncertain. Through 147 games, Pittsburgh ranks 30th in OPS and 30th in runs scored. For the season, Washington ranks 23rd in OPS and 21st in runs scored. Take the Pirates to win on the road. Final Score Prediction, Pittsburgh Pirates win 5-3.
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