San Diego Padres vs Chicago Cubs Picks and Prediction for Thursday October 2 2025
Padres Preview
A spot in the National League Division Round will be up for grabs on Thursday, when the San Diego Padres square off against the Chicago Cubs from Historic Wrigley Field. Be ready for the baseball season with all of our MLB predictions. The fifth-seeded Padres have won eight of their last 11 games and are in search of their first World Series title in franchise history. In Game Two, All-Star 3B Manny Machado hit a two-run blast to lead San Diego to a 3-1 road victory.
Thirty-nine year old righty Yu Darvish (5-5 5.38 ERA) will take the mound for the Padres in this matchup. San Diego has won Darvish’s previous four starts and he has surrendered ten runs across his last 20 plus frames.
Cubs Preview
The Chicago Cubs won 50 of 81 home games during the regular season and are looking to advance to the divisional round for the first time since 2017. During yesterday’s home loss, Chicago batters managed just four hits and struck out 11 times. Opener Andrew Kittredge gave up a sacrifice fly in the first inning and took the loss for the Cubs.
Chicago manager Craig Counsell will give the nod to veteran right-hander Jameson Taillon (11-7 3.68 ERA) on Thursday. Last time out, Taillon (6 IP) allowed one run and fanned eight batters during a 7-3 home victory versus St. Louis.
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Padres vs Cubs Pick
San Diego OF Ramon Laureano suffered a fractured finger and will not be able to play in this series. Through 162 games, San Diego ranks 16th in OPS and 18th in runs scored. For the season, Chicago ranks 7th in OPS and 5th in runs scored. Take the Cubs to win at home. Final Score Prediction, Chicago Cubs win 4-3.
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