San Francisco Giants vs Arizona Diamondbacks Picks and Predictions for Monday, September 15, 2025

By: David Anicetti Published 09/15/2025, 12:15 AM ET

The San Francisco Giants and Arizona Diamondbacks meet Monday night at Chase Field in Phoenix, with the first pitch at 9:40 PM ET on MLB.TV. San Francisco is 75–73 (37–37 away) and Arizona is 74–75 (38–34 home). San Francisco has not announced its starting pitcher, while the Diamondbacks will send Zac Gallen (11–14, 4.84 ERA, 1.28 WHIP) to the mound. Build your bankroll with our MLB Picks.

San Francisco Giants Preview

San Francisco has gone 3-2 in the last five. San Francisco lost to the Los Angeles Dodgers 13-7 on Saturday. The Giants’ strength this season has been on the mound with a 3.80 team ERA and 1.29 WHIP. San Francisco trails first place in the West by 8 games and is two games behind the third and final NL wild card spot with only 14 games remaining on the regular season schedule.

The lineup has shown some power but hits in streaks. The Giants have a slash line of .238/.313/.391 with 160 home runs. Willy Adames leads with 28 homers and 82 RBI, Heliot Ramos paces them in hits (148), and Jung Hoo Lee owns the top average (.267). When San Francisco is performing well, it strings together walks and line drives, then lets Adames or Matt Chapman empty the bases with power.

Arizona Diamondbacks Preview

Arizona defeated the Minnesota Twins 5-2 on Saturday and completes its series on the road with Minnesota on Sunday. The pitching staff has been less effective than the Giants (4.49 ERA, 1.32 WHIP). Zac Gallen has a strikeout punch (157 Ks in 174.2 IP), but has been prone to giving up the long ball (28 home runs allowed). Arizona trails first place in the National League West by 9.5 games, and is four games behind the 3rd and Final NL wild card spot.

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The offense has performed better than San Francisco’s: .250/.323/.434 with 202 home runs and 737 runs. Geraldo Perdomo leads in average and runs batted in (.286, 95 RBI), and Corbin Carroll supplies speed and power (30 home runs, 28 stolen bases).

San Francisco Giants vs Arizona Diamondbacks Prediction

The Diamondbacks will win. Arizona’s deeper offense and Gallen’s strikeout ability are small advantages but enough to win, especially at home. Both teams are battling for an NL wildcard berth, and Arizona will inch closer to San Francisco in that race with a win on Monday. Final Score Prediction: Arizona Diamondbacks win 5-4