Seattle Mariners vs St. Louis Cardinals Picks and Predictions for Friday April 24 2026

By: Kim Smith Published 04/24/2026, 12:55 AM ET

The Seattle Mariners travel to take on the St. Louis Cardinals at Busch Stadium in St. Louis, Missouri, on Friday, April 24, 2026, with first pitch scheduled for 8:15 PM and coverage available on MLB.TV. The current odds list Seattle as a -163 favorite on the moneyline, while St. Louis sits at +135, with the total set at 7.5 runs. The Mariners are listed at -1.5 on the run line at +109, while the Cardinals are +1.5 at -131. This matchup features two teams with different home and road dynamics, and readers are encouraged to check out free MLB picks for more daily insights.

Starting Pitchers Set the Tone in St. Louis

Seattle will send George Kirby to the mound, entering with a 3-2 record, a 2.97 ERA, and a 1.05 WHIP across 33.1 innings. He has allowed 27 hits while striking out 27 batters and issuing 8 walks, giving up four home runs. St. Louis counters with Andre Pallante, who comes in with a 2-1 record, a 4.05 ERA, and a 1.45 WHIP over 20.0 innings. Pallante has allowed 18 hits, struck out 12, walked 11, and surrendered two home runs.

Seattle Trying to Overcome Road Struggles

The Mariners enter this contest with an 11-15 overall record but have struggled significantly on the road, posting a 1-8 mark away from home. Over their last five games, Seattle has recently won over Oakland once and Texas twice, while also recently losing to Oakland twice. This stretch shows a team that has been competitive but has not consistently turned those efforts into wins, particularly when traveling.

Seattle is hitting .226 as a team with 101 runs scored on 193 hits, including 25 home runs. They have posted a .320 on-base percentage and a .363 slugging percentage. On the pitching side, the Mariners have recorded a 3.42 ERA with a 1.22 WHIP, allowing opponents to hit .255 while striking out 217 batters and issuing 63 walks.

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One key strength for Seattle is its pitching consistency, as reflected by the 3.42 ERA and relatively low WHIP. This has allowed them to stay in games even when the offense has been inconsistent, though their road struggles remain a concern.

St. Louis Looking to Capitalize at Home

The Cardinals come into this matchup with a 14-10 overall record and a 7-5 mark at home. In their last five games, St. Louis has recently won over Houston twice and Miami once, while also recently losing to Miami twice. This recent stretch reflects a team that has shown balance but has not fully separated itself in terms of consistency.

St. Louis is hitting .228 with 112 runs scored on 182 hits, including 27 home runs. They hold a .320 on-base percentage and a .372 slugging percentage. On the pitching side, the Cardinals carry a 4.77 ERA and a 1.43 WHIP, allowing opponents to hit .257 while striking out 154 batters and issuing 97 walks.

A notable weakness for St. Louis is its pitching profile, as indicated by the 4.77 ERA and 1.43 WHIP. These numbers suggest that opposing offenses have been able to generate opportunities, which could be a factor against a team capable of producing runs.

Seattle Mariners vs St. Louis Cardinals Picks and Prediction

Seattle Mariners vs St. Louis Cardinals Pick

Pick: Seattle Mariners Moneyline

Seattle is the preferred side in this matchup based on its pitching advantage and starting pitcher metrics. The Mariners have a lower team ERA and WHIP compared to St. Louis, and their starting pitcher enters with a lower ERA and WHIP as well. While Seattle has struggled on the road, the overall pitching edge gives them the advantage in this contest.

Seattle Mariners vs St. Louis Cardinals Total Pick

Pick: Under 7.5

I would lean toward the under in this matchup because Seattle’s pitching numbers suggest they can limit scoring, while St. Louis has shown inconsistency on the mound. With Seattle carrying a 3.42 ERA and St. Louis dealing with a higher ERA but still capable of limiting explosive scoring, this game projects to stay under the total.

Final Score Prediction: Seattle Mariners 4 – St. Louis Cardinals 2