Seattle Mariners vs St. Louis Cardinals Picks and Predictions for Saturday April 25 2026
The Seattle Mariners travel to face the St. Louis Cardinals at Busch Stadium in St. Louis, Missouri on Saturday, April 25, 2026, with first pitch scheduled for 2:15 PM and coverage available on MLB.TV. At the time of this writing the odds were not released. This matchup presents a tight contest according to projections, with both teams nearly even heading into the afternoon. Make sure to check out our free MLB picks.
Starting Pitchers Breakdown
Seattle is expected to send Bryan Woo to the mound, while St. Louis counters with Matthew Liberatore. Woo enters with a 1-2 record, a sharp 2.25 ERA, and an impressive 0.88 WHIP across 32.0 innings, allowing just 22 hits while striking out 26 batters and issuing only six walks without surrendering a home run. On the other side, Liberatore holds a 0-1 record with a 3.67 ERA and a 1.41 WHIP over 27.0 innings. He has allowed 28 hits, struck out 16, walked 10, and given up five home runs, showing some vulnerability compared to his counterpart.
Seattle’s Recent Form and Road Challenges
Seattle enters this game with an 11-15 overall record and has struggled significantly away from home, going just 1-8 on the road. Despite those road issues, the team has shown flashes recently, having recently won over Oakland 5-4 and previously defeated Texas twice, while also recently losing to Oakland in consecutive games. That mixed stretch highlights inconsistency, particularly when stepping outside their home environment.
From a statistical standpoint, the Mariners are hitting .226 with 101 runs and 193 hits, along with 25 home runs. Their on-base percentage sits at .320, paired with a .363 slugging percentage. On the pitching side, they have been more reliable, posting a 3.42 ERA with a 1.22 WHIP, while limiting opposing hitters to a .255 average. They have also recorded 217 strikeouts against just 63 walks, which reflects strong command.
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The most notable strength for Seattle lies in its pitching efficiency. The combination of a solid ERA and controlled walk rate has allowed them to stay competitive even when the offense has not been explosive. That pitching consistency could be a key factor in this matchup.
St. Louis Looking to Defend Home Field
St. Louis comes into this contest with a 14-10 overall record and a respectable 7-5 mark at home. Their recent stretch has been somewhat uneven, as they recently lost to Miami 4-1 but also picked up wins over Miami and Houston, including a high-scoring extra-inning victory. That pattern suggests a team capable of bouncing back quickly, even after setbacks.
Offensively, the Cardinals hold a slight edge with a .229 batting average, producing 112 runs on 183 hits and 27 home runs. Their .321 on-base percentage and .375 slugging percentage show a lineup that can generate scoring opportunities. However, their pitching staff has been less consistent, carrying a 4.77 ERA and a 1.43 WHIP, while allowing a .257 opponent batting average and issuing 97 walks.
The key concern for St. Louis is its pitching control and run prevention. While the offense has been productive, the elevated ERA and WHIP suggest that opposing teams are finding ways to generate offense, which could put pressure on them in a matchup against a solid opposing starter.
Mariners vs Cardinals Picks and Prediction
Mariners vs Cardinals Pick
Pick: Mariners Moneyline
Seattle’s advantage on the mound stands out in this matchup. Bryan Woo has been extremely efficient, limiting baserunners and preventing damage, which contrasts with Matthew Liberatore’s higher WHIP and home run allowance. While the Mariners have struggled on the road, their pitching staff overall has been more reliable than St. Louis, which has shown inconsistency with a 4.77 team ERA. If Woo continues his current form, Seattle has a strong chance to control the pace of the game and take advantage of St. Louis pitching that has allowed more traffic on the bases.
Mariners vs Cardinals Total Pick
Pick: Under 8.5
I’m leaning toward the under here because Seattle’s pitching has been steady, and Woo’s ability to limit hits and walks suggests this game may not turn into a high-scoring affair. While St. Louis has produced offensively, their inconsistency combined with Seattle’s lower ERA points toward a more controlled game. If the Mariners’ pitching holds firm early, this could stay under the total.
Final Score Prediction: Seattle Mariners 4 – St. Louis Cardinals 3
This prediction was written before the completion of game play on Friday.
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