St. Louis Cardinals vs Chicago Cubs Picks and Predictions for Sunday, August 16th, 2026

By: Cameron Ross Published 08/16/2026, 12:15 AM ET

Cardinals vs Cubs Game Information

The Saint Louis Cardinals continue a road trip Sunday afternoon with a 3:00 PM game in Chicago inside Wrigley Field against the Chicago Cubs. Saint Louis is 1 game above .500 coming into Sunday, having won 3 of the last 4 following the win in Game 2 of this set. The Chicago Cubs are 20 games above .500, currently 3.5 games back in the National League Central, having won 3 of the last 5 after the loss on Saturday. Stay in the news with our MLB Picks.

Cardinals Preview

The St. Louis Cardinals offense has a .240 batting average and has scored 529 runs on 977 hits this season. Saint Louis has a .315 OBP and a .377 slugging percentage. The St. Louis pitching has been shaky this season with a 4.07 team ERA, though they have allowed 5 total runs across their last 3 wins. Alec Burleson leads Saint Louis this season with a .285 batting average and 86 RBI's. Jordan Walker has a .280 batting average and leads the team with 23 home runs.

Cubs Preview

The Chicago Cubs offense has been their biggest strength this season, with a .249 batting average. Chicago has scored 637 runs on 1051 hits. Chicago has a .338 OBP and a .418 team slugging percentage. The Chicago pitching staff has compiled a 4.07 ERA but has given up 15 runs across their last 2 losses. Pete Crow-Armstrong is an NL MVP candidate, leading Chicago with a .277 batting average and 27 home runs. Seiya Suzuki has a .274 batting average and leads the team with 73 RBI's.

Cardinals vs Cubs Pitching Matchup

Hunter Dobbins will be on the mound Sunday for the Cardinals in the series finale. Dobbins is 2-3 this year with a 3.40 ERA across 45 innings of work. Edward Cabrera will counter for the Cubs. Cabrera is 5-4 this year with a 5.10 ERA through 72.1 innings of work.

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Cardinals vs Cubs Pick

Though St. Louis has the better pitching in this matchup, the Cubs offense will be the difference in this game. Chicago must get back to their winning ways, as they are in hot pursuit of the top spot in the National League Central. Take Chicago to salvage this series with another win Sunday afternoon at home against the Saint Louis Cardinals.

Pick: Chicago Cubs -162
Secondary: Over
Lean: Pete Crow-Armstrong Over 1.5 Bases

Final Score Prediction: Chicago Cubs win 7-3.