St. Louis Cardinals vs Milwaukee Brewers Picks and Predictions for Saturday, September 13, 2025
Cardinals vs Brewers Game Information
The Cardinals and Brewers meet again at American Family Field in a division clash with very different stakes. Milwaukee enters at 89-58 and is closing in on a division crown, while St. Louis sits at 72-75 and is on the outside looking in at the Wild Card race. The Brewers have dominated the head-to-head series this season, winning three of the first four matchups, and ESPN Analytics gives them a 61.2% chance to take this one as well. First pitch is set for 6:15 PM ET on FOX with conditions at 71 degrees in Milwaukee. Batter up! Swing for profits with sharp mlb picks.
Cardinals Preview
St. Louis has had a rough September, losing three straight to Seattle before this series. The offense has not been able to generate consistency, scoring just two or three runs in each of those losses. Willson Contreras remains the centerpiece with 20 homers and 78 RBI, while Alec Burleson leads the team in batting average at .282 with a .331 OBP. The Cardinals as a whole are hitting .244 with 138 home runs, ranking behind Milwaukee in nearly every key offensive category. The pitching staff carries a 4.26 ERA and 1.31 WHIP, allowing opponents to hit .258, which has left the club fighting uphill in most games.
Sonny Gray will get the start for St. Louis, and while he has 13 wins, his numbers have been uneven. Gray has a 4.45 ERA and 1.22 WHIP through 163.2 innings, giving up 165 hits and 23 home runs while striking out 179. He has shown swing-and-miss ability but has struggled with the long ball, an issue against a Milwaukee team with power throughout the lineup. The Cardinals need him to keep the ball down and avoid early damage to stay competitive.
Brewers Preview
Milwaukee has been rolling behind one of the most balanced rosters in the National League. Christian Yelich has been the offensive leader with 27 home runs, 93 RBI, and a .267 average, while Sal Frelick has chipped in a .294 average and .358 OBP. As a group, the Brewers are batting .260 with 157 homers, 743 runs scored, and a .333 OBP, numbers that put them well ahead of St. Louis in run production. The pitching staff has also been outstanding with a 3.63 ERA, 1.23 WHIP, and opponents hitting just .230 against them.
Sign Up Get $30 Premium Picks Credit + Exclusive Offers
Subscribe Now
Brandon Woodruff takes the mound, and his form gives Milwaukee a clear edge. Woodruff is 6-2 with a 3.32 ERA, 0.96 WHIP, and 74 strikeouts in 59.2 innings. He has been nearly unhittable when locating, allowing only 43 hits and 8 home runs while issuing just 14 walks. His efficiency and command should match up well against a St. Louis lineup that has struggled to string together base runners.
Brewers vs Cardinals Prediction Reasoning
Prediction: With Milwaukee owning the better lineup, deeper bullpen, and a major edge in the pitching matchup, the Brewers are positioned to handle business at home. Woodruff’s consistency should carry the day, while Yelich and company provide enough offense to back him.
Pick: Brewers -1.5 Run Line
Final Score: Brewers 5, Cardinals 2
Never Tried Picks and Parlays? Now Is Your Chance
- Get your first daily picks package for ONLY $1 using coupon code BUCK
- If the pick loses, we credit your account with 3 Flex Picks
- If the pick wins, we still give you 1 Flex Pick on the house
- Win or lose, you walk away ahead. One dollar. No catch.
Spend $10 Get 200 in Bonus Picks
$200 in No Sweat Entries + A Free Pick
Get 100% on any coins purchase up to $100
Best Picks:
- Brewers -1.5
- Full Game Under 8.5
- Christian Yelich to Record an RBI
