St. Louis Cardinals vs Philadelphia Phillies Picks and Prediction for Saturday August 22 2026

By: Eddie Kline Published 08/22/2026, 12:15 AM ET

Cardinals Preview

Citizens Bank Park will play host to a Saturday evening MLB clash between the St. Louis Cardinals and the Philadelphia Phillies. Be ready for the baseball season with all of our MLB predictions. The Cardinals were picked to finish last in the NL Central Division, but still have a 11 percent chance to reach the postseason. All-Star OF Jordan Walker ranks second in the majors with 94 RBIs and leads St. Louis with 26 home runs. 1B Alec Burleson is one RBI behind Walker and leads the Cardinals with a .288 batting average. 

Twenty-seven year old righty Andre Pallante (12-6 3.57 ERA) is quietly putting together a career year for the Cardinals. Over his previous five starts, Pallante (30.2 IP) has allowed just seven runs and fanned 22 batters. Pallante has not surrendered a long ball in more than a month. 

Phillies Preview

The Philadelphia Phillies stumbled out of the gate this season, but are sitting with a 90 percent change to qualify for the playoffs. The Phillies are starting to catch fire the last two weeks and still have a chance to reel in Atlanta for the top spot in the NL East Division. All-Star DH Kyle Schwarber has clubbed a major league best 37 home runs. 1B Bryce Harper is hitting .260 to go along with 25 home runs and 72 RBIs. 

Rookie right-hander Andrew Painter (2-8 6.43 ERA) will make his 17th career major league start for the Phillies. Through 85 plus innings, Painter has issued 34 bases on balls and served up 17 home runs while posting a subpar 1.55 WHIP. 

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Cardinals vs Phillies Pick

St. Louis 3B (elbow) is on a rehab assignment with Triple-A Memphis and could return to the lineup next week. Through 130 games, St. Louis ranks 24th in OPS and 17th in runs scored. For the season, Philadelphia ranks 19th in OPS and 15th in runs scored. Take the Cardinals to win on the road. Final Score Prediction, St. Louis Cardinals win 6-3. This preview was completed prior to game play on Friday. 

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