St. Louis Cardinals vs Seattle Mariners Picks and Predictions for Monday, September 8, 2025

By: David Anicetti Published 09/08/2025, 12:20 AM ET

The St. Louis Cardinals visit the Seattle Mariners on Monday night at T-Mobile Park, with the first pitch set for 9:40 PM ET. St. Louis enters at 71-72 and 31-38 on the road, while Seattle sits at 74-68 with a 41-27 home record. Seattle is second to Houston in the American League West and currently holds the third and final AL wildcard spot. St. Louis is well off the pace for playoff contention. Our free MLB picks give you a great chance to win.

St. Louis Cardinals Preview

At the plate, the Cardinals rely on Alec Burleson and Willson Contreras. Burleson leads the team with a .286 average, while Contreras has delivered 20 homers and 78 RBIs despite recent suspension issues. St. Louis is batting .246 with 136 homers and 618 runs. With Brendan Donovan and Burleson both on the injured list as of September 8, the lineup’s depth will be tested against one of the league’s tougher pitching staffs.

Miles Mikolas starts for St. Louis, with a 7-10 record with a 4.89 ERA and 1.33 WHIP over 136.1 innings. The right-hander has allowed 149 hits with 33 walks and 86 strikeouts, leaving little margin for error against a strong Seattle lineup. The Cardinals’ staff has a 4.28 ERA and 1.32 WHIP overall, and opponents are batting .259 against them.

Seattle Mariners Preview

The Mariners bring power, led by Cal Raleigh’s 52 home runs and 110 RBI. Julio Rodriguez is batting .265, with a .475 slugging percentage, and a team-best 154 hits. Seattle’s lineup has 205 homers and 649 runs while hitting .241 overall, leaning on slugging more than contact, which has helped to keep them in the AL West chase.

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Seattle counters with Bryan Woo, who has been excellent at 12-7 with a 3.02 ERA, 0.97 WHIP, and 169 strikeouts in 169.2 innings. Woo has been dominant at limiting base runners, holding opponents to just 130 hits. The Mariners’ pitching overall shows a 4.03 ERA and 1.26 WHIP, keeping them in games even when the bats are not producing.

Mariners vs Cardinals Prediction

Bryan Woo’s form on the mound and Seattle’s power create a clear edge for the Mariners at home, especially with St. Louis shorthanded in the lineup. Final Score Prediction: Seattle Mariners win 7-2.