St. Louis Cardinals vs Washington Nationals Picks and Predictions for Monday, April 6, 2026

By: Cameron Ross Published 04/06/2026, 01:25 AM ET

Cardinals vs Nationals Game Information

The Saint Louis Cardinals will be on the road Monday night for game one of a three-game set inside Nationals Park in Washington against the Washington Nationals. Saint Louis has five wins and four losses coming into this matchup, having won three of the last five following a two-run road victory against the Detroit Tigers in their last outing to end the two-game skid. The Washington Nationals stay home one day with three wins and six losses this season, riding a lengthy losing streak after being swept by the Los Angeles Dodgers. Stay in the news with our MLB Picks.

Cardinals Preview

The Saint Louis offense has been mediocre this season, with a .220 batting average. The Cardinals scored 35 runs on 58 hits. Saint Louis has a .299 team OBP and a .352 team slugging percentage. Saint Louis pitching has struggled immensely, with a 5.18 team ERA, but the team has allowed four total runs over their last three wins. Nolan Gorman has supplied the power to the Saint Louis offense this season, leading the team with two home runs on the year. Victor Scott II leads the team with a .310 batting average, and Jordan Walker has posted a team high of eight RBI's through nine games played this season.

Nationals Preview

The Washington Nationals offense has been solid this season, with a .278 batting average. The Nationals scored 49 runs on 80 hits. Washington has a .344 team OBP and a .434 team slugging percentage. The Washington pitching has been their biggest issue as the Nationals have a 6.04 team ERA this season. Luis Garcia Jr. leads the Washington offense this season with a .324 batting average. CJ Abrams and the team both had three home runs and twelve RBI's on the year.

Cardinals vs Nationals Pitching Matchup

Saint Louis has a huge edge on the mound as they send out a pitcher who was undefeated thus far this season with a 0.00 ERA through 5 innings of work. Washington counters with Zach Littell, who has struggled immensely this season, winless through one start with a 5.40 ERA. Look for Saint Louis to back the better pitcher in this matchup, leading to the win.

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Cardinals vs Nationals Pick

The Washington Nationals do have the better offense in this matchup, but they have struggled immensely this season. The Washington pitching is horrendous, and they send out a bad arm to start Monday's game. Look for the Saint Louis Cardinals to jump on the poor pitching as they spark their offense in this matchup. Take Saint Louis Monday night to do the job as they get their second consecutive win with a victory in Washington.

Pick: St. Louis Cardinals -112
Secondary: Under 8
Lean: Nolan Gorman Over .5 RBI’s

Final Score Prediction: St. Louis Cardinals win 3-1