Tampa Bay Rays vs Chicago White Sox Picks and Predictions for Wednesday, April 15, 2026

By: Cameron Ross Published 04/15/2026, 01:35 AM ET

Rays vs White Sox Game Information

The Tampa Bay Rays stay on the road Wednesday night for game two of three in Chicago, IL, inside Guaranteed Rate Field at 7:40 PM against the Chicago White Sox. Tampa Bay has nine wins and seven losses this season, coming into Wednesday on a four-game winning streak after a three-run victory in Game 1 of this set. The Chicago White Sox stay on their home field Wednesday night, five games below .500 after losing 3 of the last five following the loss on Tuesday night. Stay in the action with our MLB Picks.

Rays Preview

The Tampa Bay offense has been solid this season, with a .260 batting average. Tampa Bay has scored seventeen runs on 135 hits, and the team that scored 23 runs during their current 4-game winning streak. The Tampa Bay pitching has been shaky, however, with a 4.59 team ERA. Chandler Simpson leads the way for the Tampa Bay offense this season with a .407 batting average. Yandy Diaz leads the team with three home runs and fifteen RBI's this season.

White Sox Preview

The Chicago White Sox have been a terrible offensive team this season, with a .193 batting average. The White Sox have scored only 49 runs on 98 hits. The Chicago pitching has been even worse with a 4.70 ERA this season. Chase Meidroth leads the Chicago offense this season with a .203 batting average. Munetaka Murakami has supplied the power to the Chicago offense this season, leading the team with five home runs and nine RBI's.

Rays vs White Sox Pitching Matchup

Jesse Scholtens will get the start for Tampa Bay this season, winless thus far this year with a 0.00 ERA through 4.2 innings of work. Sean Burke will counter for the White Sox, winless thus far this season with a 3.60 ERA over 15 innings.

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Rays vs White Sox Pick

Tampa Bay is the far better team in this matchup, playing great baseball coming into Wednesday. Look for the Tampa Bay Rays to overwhelm me, a terrible Chicago team from the opening pitch. Take the race to continue their winning ways Wednesday night as they get the win on the road in Chicago for the second time in two days.

Pick: Tampa Bay Rays -115
Secondary: Over 8
Lean: Chandler Simpson Over 1.5 Bases

Final Score Prediction: Tampa Bay Rays win 7-3.